Results 81 to 90 of about 1,307 (196)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sonic Anti-Correlationism and its Limits: Thinking Quentin Meillassoux with William Basinski
, 2021 The Sound of the Non-Correlational How do we theorize the relationship between the human and the nonhuman? How should this relationship be conceptualized within the field of sound studies? What are the political and conceptual stakes of how we posit the human and the nonhuman?
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Territorial assemblages simulation for territorial intelligence
, 2011 International audienceThe following article is based on the theory of assemblage ontology seen as a framework to formalize new projects territories in a perspective of territorial intelligence. The area of research is PARIS-SACLAY Campus, which views the
Bugeaud, Florie +6 more
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The Struggle with Correlationism: Speculative Realism against Heidegger
RUDN Journal of PhilosophyThe main problem that speculative realism, represented by Quentin Meillassoux, Graham Harman and Ray Brassier, is trying to solve is overcoming correlationism. Two important figures who played a key role in the development of correlationism are Immanuel Kant and Martin Heidegger.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Agency From A Stone: Shelley’s Posthumanist Experiments In Mont Blanc [PDF]
, 2016 This article reads Shelley’s ‘Mont Blanc’ as an extended exploration into possible modes of relationship linking the human mind to the material world.
Bolton, Betsy
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Halfway to paradise: documenting people and place, fictional constructs and considerations for post-documentary [PDF]
Dr Deverell explored the potential for video art to move past documentary into post-documentary. The research considered how established conventions in documentary practice are being contested and expanded with the growing dispersal and dissipation of ...
Deverell, K
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source