Results 81 to 90 of about 515 (205)

Realism without Speculation : Heidegger, Meillassoux and the Question of Philosophical Method [PDF]

open access: yes, 2017
In this article, we evaluate Meillassoux’s criticism of correlationism in general and of Heidegger’s correlationism in particular. Contrary to earlier contributions, we argue that Meillassoux’s reflections on uncorrelated being not only serve an ...
Blok, Vincent
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

On the Principles of Contradiction and Correlationism in the Wittgenstein’s Tractatus Logico-Philosophicus [PDF]

open access: yes, 2019
The article is devoted to the discussing the principle of contradiction in Tractatus Logico-Philosophicus. The author shows how this principle is violated only indirectly.
Kustov, S., Кустов, С. А.
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Speculative Materialism or Pragmatic Naturalism? Sellars contra Meillassoux [PDF]

open access: yes, 2017
Meillassoux's criticism of correlationism and the alternative he proposes are compared with Sellars's rationalistic pragmatism. I argue that Meillssoux's rejection of the principle of sufficient reason undermines the intelligibility of science itself ...
Sachs, Carl
core   +2 more sources

Beyond Correlationism: Translation as a Pre-Subjective Ontological Structure [PDF]

open access: yes
Meillassoux’s critique of correlationism establishes one of the most productive fault-lines in contemporary metaphysics: if every philosophical framework conditions being upon some form of access — experiential, cognitive, or conceptual — then genuine ...
Sueyoshi, Makoto
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

„Nowa” polityka państwa w obszarze kultury wizualnej. Projekt

open access: yesZarządzanie w Kulturze
The paper aims at diagnosing the underlying causes for the state of visual culture in Poland and indicating the directions of the new cultural policy for the country.
Jan Stanisław Wojciechowski
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

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