Results 101 to 110 of about 401 (212)
AGI-Correlationism and Its Discontents
Információs TársadalomAnthropocentric and anthropomorphic biases and attitudes have been present inartificial intelligence (AI) research and practice since their beginning, being especiallynoticeable in artificial general intelligence. The aim of this paper is to proposea comprehensive framework for critical observation, as well as general theoreticalinquiry into these ...
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Loss of the Great Outdoors:Neither Correlationist Gem nor Kantian Catastrophe [PDF]
, 2017 This article concerns Quentin Meillassoux’s claim that Kant’s revolution is responsible for philosophy’s catastrophic loss of the ‘great outdoors’, of our knowledge of things as they are in themselves. I argue that Meillassoux’s critique of Kant’s ‘weak’
Lovat, Toby
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Algorithm reality – intentionality and instrumentality
Интеллект. Инновации. ИнвестицииThis article presents a philosophical analysis of algorithms through the synthesis of Edmund Husserl’s concept of intentionality and Martin Heidegger’s instrumentality, revealing their ontological status as phenomena that connect consciousness and ...
V. Е. Kukel
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 2016 The aim of this paper is threefold. First, we examine the Sellarsian concept of the (myth of the) categorial Given, focus on its wide application and suggest that it can be applied to those post-Kantian philosophical views, currently fashionable in ...
Christias, D.
core
, 2021 The article examines the position of representatives of speculative realism, a new direction in philosophy. The approaches of Quentin Meillassoux and Graham Harman to solving the problem of correlationism are presented, and the essence of the problem of ...
Malyshev, V. N.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source