Results 81 to 90 of about 390,681 (199)
Advanced Science, Volume 13, Issue 58, 19 October 2026.Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley +1 more source
Blood transcriptomic signatures of vascular risk in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Lifestyle and environmental factors contributing to cardiovascular risk are components of the exposome, yet molecular signatures associated with cumulative cardiovascular risk in Alzheimer's disease (AD) remain incompletely understood.
Sang‐Won Han +6 more
wiley +1 more source
Memory-Efficient High-Speed Implementation of Kyber on Cortex-M4
, 2019 This paper presents an optimized software implementation of the module-lattice-based key-encapsulation mechanism Kyber for the ARM Cortex-M4 microcontroller. Kyber is one of the round-2 candidates in the NIST post-quantum project. In the center of our work are novel optimization techniques for the number-theoretic transform (NTT) inside Kyber, which ...
Botros, Leon +2 more
openaire +4 more sources
Anterior cingulate cortex neuron subtypes differentially regulate seizures
Epilepsia, Volume 67, Issue 10, Page 5531-5546, October 2026.Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan +12 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 7, Page 1588-1601, 1 October 2026.ABSTRACT The standard for assessing and recording the extent of the tumour, a necessity for most malignancies, is the Tumour Node Metastases (TNM) classification. The Union for International Cancer Control (UICC) TNM committee has defined this since the early 1950s.
James D. Brierley +8 more
wiley +1 more source
Next‐Generation Brain Health Monitoring Enabled by Integrated Wearable AI Infrastructure
Smart Medicine, Volume 5, Issue 5, October 2026.This review presents an integrated framework for next‐generation brain‐health monitoring that connects molecular pathology to digital biomarkers via multimodal wearable sensing, signal processing, and AI‐driven analytics. It highlights advances in sensor design, data quality, edge computing, artificial intelligence, digital twins, and clinical ...
Muhammad Hasan Masrur +4 more
wiley +1 more source
Alterations in cholinergic functions have been reported to be associated with neuropsychiatric symptoms in dementia. Increased M1 muscarinic receptor binding in temporal cortex is associated with delusions in dementia with Lewy bodies (DLB) patients and ...
Mckeith IG +5 more
core +4 more sources
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm
British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley +1 more source
Motivational Biases in Go and Nogo Learning From Immediate Versus Delayed Feedback
European Journal of Neuroscience, Volume 64, Issue 8, October 2026.Motivational biases have been proposed to originate from the striatum, which is more strongly involved in learning from immediate than delayed feedback. Despite this presumed difference, motivational biases emerged during learning from both immediate and delayed feedback, suggesting they are a hardwired and robust hallmark of decision‐making.
Julian Vahedi +4 more
wiley +1 more source