Results 61 to 70 of about 1,669,272 (363)

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

The role of precuneus and left inferior frontal cortex during source memory episodic retrieval [PDF]

, 2005
The posterior medial parietal cortex and left prefrontal cortex (PFC) have both been implicated in the recollection of past episodes. In a previous study, we found the posterior precuneus and left lateral inferior frontal cortex to be activated during ...
Baddeley, Baddeley, Bookheimer, Brian Nils Lundstrom, Buckner, Buckner, Cabeza, Dobbins, Dobbins, Eichenbaum, Fiez, Fiez, Fletcher, Fletcher, Fletcher, Friston, Friston, Friston, Gonsalves, Grasby, Hagoort, Holmes, Johansson, Kahn, Karl Magnus Petersson, Kelley, Konishi, Krause, Lundstrom, Mandler, Marsh, Martin Ingvar, Nolde, Nolde, Nyberg, Petersson, Poldrack, Rugg, Rugg, Rugg, Rugg, Rugg, Rugg, Schacter, Schacter, Shallice, Slotnick, Snodgrass, Takahashi, Talairach, Thompson-Schill, Tulving, Wagner, Wagner, Wheeler, Wheeler, Yonelinas   +56 more
core   +3 more sources

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

eLife, 2019
Sensation and action are necessarily coupled during stimulus perception – while tasting, for instance, perception happens while an animal decides to expel or swallow the substance in the mouth (the former via a behavior known as ‘gaping’).
Narendra Mukherjee, Joseph Wachutka, Donald B Katz   +2 more
doaj   +1 more source

Apical length governs computational diversity of layer 5 pyramidal neurons

eLife, 2020
Anatomical similarity across the neocortex has led to the common assumption that the circuitry is modular and performs stereotyped computations. Layer 5 pyramidal neurons (L5PNs) in particular are thought to be central to cortical computation because of ...
Alessandro R Galloni, Aeron Laffere, Ede Rancz   +2 more
doaj   +1 more source

The topology of connections between rat prefrontal, motor and sensory cortices [PDF]

, 2014
The connections of prefrontal cortex (PFC) were investigated in the rat brain to determine the order and location of input and output connections to motor and somatosensory cortex.
Agster, Alvarez, Aronoff, Berendse, Botvinick, Canto, Chris J. Tinsley, Courchesne, Dinopoulos, E. Ellen Billett, Frysztak, Fujita, Fuster, Gabbott, Gallagher, Goldman-Rakic, Hafting, Henry, Hoover, Hoover, Jonathan J. Crofts, Kim, Kim, Kolb, Kondo, Lee, Narayanan, Narayanan, Narayanan, Neafsey, Olson, Paxinos, Perlstein, Porter, Schilman, Schoenbaum, Schoenbaum, Sesack, Stacey A. Bedwell, Thivierge, Van De Werd, Vertes, Vertes, Welker, Woolsey   +44 more
core   +2 more sources

Comprehensive end‐to‐end dosimetry audit for stereotactic body radiotherapy in spine, lung, and soft tissue

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose To create and conduct a comprehensive onsite end‐to‐end dosimetry audit to assess treatment accuracy of spine, lung, and soft tissue Stereotactic Body Radiotherapy (SBRT) across Australian and New Zealand (ANZ) radiotherapy centers. Methods The Australian Clinical Dosimetry Service (ACDS) anthropomorphic thorax phantom underwent a CT ...
Maddison Shaw, Andrew Alves, Jessica Lye, Joerg Lehmann, Fayz Kadeer, Sabeena Beveridge, Nicholas Hardcastle, Moshi Geso, Rhonda Brown   +8 more
wiley   +1 more source

Long-range population dynamics of anatomically defined neocortical networks

eLife, 2016
The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex.
Jerry L Chen, Fabian F Voigt, Mitra Javadzadeh, Roland Krueppel, Fritjof Helmchen   +4 more
doaj   +1 more source

A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

eLife, 2020
During the development of the cerebral cortex, neurons are generated directly from radial glial cells or indirectly via basal progenitors. The balance between these division modes determines the number and types of neurons formed in the cortex thereby ...
Kerstin Hasenpusch-Theil, Christine Laclef, Matt Colligan, Eamon Fitzgerald, Katherine Howe, Emily Carroll, Shaun R Abrams, Jeremy F Reiter, Sylvie Schneider-Maunoury, Thomas Theil   +9 more
doaj   +1 more source

Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury

Pharmaceutical Biology, 2023
Context Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.Objective To explore the therapeutic effects and underlying mechanisms of HSYA on post-
En Hu, Teng Li, Zhilin Li, Hong Su, Qiuju Yan, Lei Wang, Haigang Li, Wei Zhang, Tao Tang, Yang Wang   +9 more
doaj   +1 more source