Results 51 to 60 of about 1,633,661 (305)

Investigating the Usability and Acute Effects of a Bedside Video Console to Prefrontal Cortical Activity Alterations: A Preclinical Study in Healthy Elderly

open access: yesFrontiers in Systems Neuroscience, 2017
Elderly people at risk of developing cognitive decline; e.g., following surgery, may benefit from structured, challenging, and repetitive cognitive video training.
Ruud H. Knols   +9 more
doaj   +1 more source

Division of cortical cells is regulated by auxin in Arabidopsis roots

open access: yesFrontiers in Plant Science, 2022
The root cortex transports water and nutrients absorbed by the root epidermis into the vasculature and stores substances such as starch, resins, and essential oils. The cortical cells are also deeply involved in determining epidermal cell fate.
Huijin Kim   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex

open access: yesBrain Sciences, 2016
Perineuronal nets (PNNs) are specialized extracellular matrix molecules that are associated with the closing of the critical period, among other functions. In the adult brain, PNNs surround specific types of neurons, however the expression of PNNs in the
Sarah M. Fader   +3 more
doaj   +1 more source

Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

open access: yeseLife, 2021
Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological activity, underlies several critical functions, including learning and memory. However, NREM sleep is heterogeneous, varying in duration, depth, and spatially across the
Trisha V Vaidyanathan   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors

open access: yesNature Communications
Inhibition plays a key role in brain functions. While typically linked to GABA, inhibition can be induced by glutamate via metabotropic glutamate receptors (mGluRs). Here, we investigated the role of mGluR-mediated inhibition in the habenula, a conserved,
Anna Maria Ostenrath   +13 more
doaj   +1 more source

The Cytoarchitecture of the Tectal-Related Pallium of Squirrelfish, Holocentrus sp.

open access: yesFrontiers in Neuroanatomy, 2022
The squirrelfish, which live in visually complex coral reefs, have very large eyes and a special dual-system “day and night vision” retina. They also have atypical expansions of brain areas involved in processing visual information.
Leo S. Demski, Joel A. Beaver
doaj   +1 more source

COMPARISON OF EMOTIONAL RESPONSES IN MONKEYS WITH RHINAL CORTEX OR AMYGDALA LESIONS [PDF]

open access: yes, 2002
Four emotionally arousing stimuli were used to probe the behavior of monkeys with bilateral ablations of the entorhinal and perirhinal cortex. The animals’ behavioral changes were then contrasted with those observed earlier (Meunier et al., 1999) in ...
Bachevalier, PhD Jocelyne   +1 more
core   +1 more source

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