Results 71 to 80 of about 1,008,844 (388)

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

eLife, 2019
We investigated afferent inputs from all areas in the frontal cortex (FC) to different subregions in the rostral anterior cingulate cortex (rACC). Using retrograde tracing in macaque monkeys, we quantified projection strength by counting retrogradely ...
Wei Tang, Saad Jbabdi, Ziyi Zhu, Michiel Cottaar, Giorgia Grisot, Julia F Lehman, Anastasia Yendiki, Suzanne N Haber   +7 more
doaj   +1 more source

The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation

Human Brain Mapping, 2022
The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory and navigation. The functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of these Posterior ...
E. Rolls, S. Wirth, G. Deco, Chu-Chung Huang, Jianfeng Feng   +4 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Spectral and temporal processing in human auditory cortex [PDF]

, 2002
Hierarchical processing suggests that spectrally and temporally complex stimuli will evoke more activation than do simple stimuli, particularly in non-primary auditory fields.
Akeroyd, MA, Haggard, MP, Hall, DA, Johnsrude, IS, Palmer, AR, Summerfield, AQ   +5 more
core   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Navigating the complex path between the oxytocin receptor gene (OXTR) and cooperation: an endophenotype approach

Frontiers in Human Neuroscience, 2013
Although cooperation represents a core facet of human social behavior there exists considerable variability across people in terms of the tendency to cooperate.
Brian W. Haas, Brian W. Haas, Ian W. Anderson, Jessica M. Smith   +3 more
doaj   +1 more source

Multi‐institutional study on image quality for a novel CBCT solution on O‐ring linac

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction This work presents a multi‐institutional study on image quality provided by a novel cone beam computed tomography (CBCT). The main goal is to investigate the consistency of imaging performance across multiple institutions.
Luis Agulles‐Pedrós, R. Lee MacDonald, Amanda Jean Cherpak, Nayha Dixit, Lei Dong, Tianyu Zhao, Kundan Thind, Anthony Doemer, Boon‐Keng Teo, Shiqin Su, Alexander Moncion, James L. Robar   +11 more
wiley   +1 more source

Localizing ECoG electrodes on the cortical anatomy without post-implantation imaging

NeuroImage: Clinical, 2014
Introduction: Electrocorticographic (ECoG) grids are placed subdurally on the cortex in people undergoing cortical resection to delineate eloquent cortex. ECoG signals have high spatial and temporal resolution and thus can be valuable for neuroscientific
Disha Gupta, N. Jeremy Hill, Matthew A. Adamo, Anthony Ritaccio, Gerwin Schalk   +4 more
doaj   +1 more source

Evaluation of the dose reduction effect of crystalline lens exposure in cone‐beam computed tomography with bismuth eye shield for image‐guided radiation therapy: An anthropomorphic phantom study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract This study aimed to evaluate the dose‐exposure reduction effect of a crystalline lens with a bismuth eye shield using cone‐beam computed tomography (CBCT) for head image‐guided radiation therapy. The ocular surface dose of the head phantom (THRA‐1) is defined as a crystalline lens exposure dose and is measured using a radiophotoluminescence ...
Tatsuya Yoshida, Koji Sasaki, Yoshiyuki Kawasaki, Tomoki Hayakawa, Toshiyuki Kawadai, Takako Shibasaki   +5 more
wiley   +1 more source