Results 61 to 70 of about 446,858 (263)

Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development

Frontiers in Cell and Developmental Biology, 2022
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial roles in ...
Ana López-Mengual, Ana López-Mengual, Ana López-Mengual, Ana López-Mengual, Miriam Segura-Feliu, Miriam Segura-Feliu, Miriam Segura-Feliu, Miriam Segura-Feliu, Raimon Sunyer, Héctor Sanz-Fraile, Jorge Otero, Jorge Otero, Francina Mesquida-Veny, Francina Mesquida-Veny, Francina Mesquida-Veny, Francina Mesquida-Veny, Vanessa Gil, Vanessa Gil, Vanessa Gil, Vanessa Gil, Arnau Hervera, Arnau Hervera, Arnau Hervera, Arnau Hervera, Isidre Ferrer, Isidre Ferrer, Isidre Ferrer, Jordi Soriano, Jordi Soriano, Xavier Trepat, Xavier Trepat, Xavier Trepat, Xavier Trepat, Ramon Farré, Ramon Farré, Ramon Farré, Daniel Navajas, Daniel Navajas, Daniel Navajas, José Antonio del Río, José Antonio del Río, José Antonio del Río, José Antonio del Río   +42 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex

Frontiers in Cellular Neuroscience
Introductionγ-Aminobutyric acid (GABA) type A receptors (GABAARs) are ligand-gated Cl-channels that mediate the bulk of inhibitory neurotransmission in the mature CNS and are targets of many drugs. During cortical development, GABAAR-mediated signals are
Kirill Zavalin, Anjana Hassan, Yueli Zhang, Zain Khera, Andre H. Lagrange, Andre H. Lagrange   +5 more
doaj   +1 more source

The Principle of Cortical Development and Evolution. [PDF]

Neurosci Bull
Abstract Human’s robust cognitive abilities, including creativity and language, are made possible, at least in large part, by evolutionary changes made to the cerebral cortex. This paper reviews the biology and evolution of mammalian cortical radial glial cells (primary neural stem cells) and introduces the concept that a genetically step ...
Yang Z.
europepmc   +3 more sources

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Evolution of Cerebral Cortical Development

Brain, Behavior and Evolution, 2011
Understanding how the human cerebral cortex evolved to its present complex state is a fascinating topic for neuroscience, genetics, bioinformatics and comparative biology. To gain further insights into the origins of the mammalian neocortex and to understand how the cortex evolved to be able to serve more complex cognitive functions, we study the ...
openaire   +3 more sources

Disorders of neurogenesis and cortical development [PDF]

Dialogues in Clinical Neuroscience, 2018
The development of the cerebral cortex requires complex sequential processes that have to be precisely orchestrated. The localization and timing of neuronal progenitor proliferation and of neuronal migration define the identity, laminar positioning, and specific connectivity of each single cortical neuron.
Guarnieri, Fabrizia Claudia, de Chevigny, Antoine, Falace, Antonio, Cardoso, Carlos   +3 more
openaire   +3 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source