Results 71 to 80 of about 68,479 (299)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source

Light aerobic exercise modulates executive function and cortical excitability

, 2020
Single bouts of aerobic exercise can modulate cortical excitability and executive cognitive function, but less is known about the effect of light‐intensity exercise, an intensity of exercise more achievable for certain clinical populations.
David Costa‐Miserachs, Stillman, Alexandra, Fried, Peter J, Gomes‐Osman, Joyce, Peter J. Fried, Emiliano Santarnecchi, Alvaro Pascual‐Leone, Timothy P. Morris, Jose Maria Tormos Muñoz, Joyce Gomes‐Osman, Joanna Macone, Morris, Timothy P, Santarnecchi, Emiliano, Tormos Muñoz, Jose Maria, Alexandra Stillman, Pascual‐Leone, Alvaro, Macone, Joanna, Costa‐Miserachs, David   +17 more
core   +1 more source

Dietary modulation of cortical excitation and inhibition [PDF]

Journal of Psychopharmacology, 2017
The balance of excitatory and inhibitory neurotransmitters in the brain affects both neural responses and behaviour in humans and animals. Here we investigated whether dietary intervention aimed at increasing levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) can influence neural responses to basic sensory stimuli.
Smith, Anika Kathryn, Wade, Alexander Robert Patrick, Penkman, Kirsty Elizabeth Helena, Baker, Daniel Hart   +3 more
openaire   +3 more sources

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Pressure pain thresholds increase after preconditioning 1 Hz repetitive transcranial magnetic stimulation with transcranial direct current stimulation. [PDF]

PLoS ONE, 2014
BackgroundThe primary motor cortex (M1) is an effective target of non-invasive cortical stimulation (NICS) for pain threshold modulation. It has been suggested that the initial level of cortical excitability of M1 plays a key role in the plastic effects ...
Tonya M Moloney, Alice G Witney
doaj   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

Advanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina, Kanghwan Kim, Wesley Charles Smith, Keuntae Kim, Shinwoo Lee, Jiwan Woo, Il‐Joo Cho   +6 more
wiley   +1 more source

Cortical excitability and neurology: insights into the pathophysiology [PDF]

, 2012
Transcranial magnetic stimulation (TMS) is a technique developed to non-invasively investigate the integrity of human motor corticospinal tracts. Over the last three decades, the use of stimulation paradigms including single-pulse TMS, paired-pulse ...
Macdonell, Richard A.L., Brodtmann, Amy, Radwa, Badawy,, Macdonell, Richard, Badawy, Radwa A.B., Loetscher, Tobias   +5 more
core  

Cortical Plasticity Induced by Anodal Transcranial Pulsed Current Stimulation Investigated by Combining Two-Photon Imaging and Electrophysiological Recording

Frontiers in Cellular Neuroscience, 2019
Anodal-transcranial pulsed current stimulation (a-tPCS) has been used in human studies to modulate cortical excitability or improve behavioral performance in recent years. Multiple studies show crucial roles of astrocytes in cortical plasticity.
Zengguang Ma, Xiaolang Du, Feifei Wang, Ran Ding, Yuanyuan Li, Aili Liu, Liangpeng Wei, Shaowei Hou, Feng Chen, Qi Hu, Cunle Guo, Qingyan Jiao, Shujing Liu, Bei Fang, Hui Shen   +14 more
doaj   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source