Results 91 to 100 of about 1,302,249 (240)

First Record of Tasmanian Devils in the Pilbara: Late Quaternary Subfossils From Juukan Gorge, Puutu Kunti Kurrama Country, and Insights Into Human—Faunal Relationships and Extinction

Archaeology in Oceania, EarlyView.
ABSTRACT This study presents the first unequivocal evidence for the presence of Tasmanian devils (Sarcophilus harrisii) in the Pilbara region of northwestern Australia, based on material recovered from archaeological excavations at Juukan Gorge on Puutu Kunti Kurrama and Pinikura country.
Timothy J. Churchill, Michael Slack, Elise Matheson, Liam Neill, Wanchese M. Saktura, Gavin Ashburton   +5 more
wiley   +1 more source

The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization

PAIN Reports, 2018
. Introduction:. Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents.
Jun Zhao, Dan Levy
doaj   +1 more source

PSD-95 uncoupling from NMDA receptors by Tat-N-dimer ameliorates neuronal depolarization in cortical spreading depression

, 2017
Cortical spreading depression is associated with activation of NMDA receptors, which interact with the postsynaptic density protein 95 (PSD-95) that binds to nitric oxide synthase (nNOS).
Strømgaard, Kristian, Lauritzen, Martin, Kucharz, Krzysztof, Søndergaard Rasmussen, Ida, Bach, Anders   +4 more
core   +1 more source

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

Aura and osmophobia are associated with the IL1A -889C > T (rs1800587) variant in migraine

Arquivos de Neuro-Psiquiatria
Background Migraine belongs to the group of primary headaches, affecting 14.4% of the global population. The pathophysiological mechanisms of migraine involve the interplay between hypothalamic activation, cortical spreading depression ...
Amanda Brant Rocha, Giovana Ortiz Zendrini, Maria Paula Bertoletti Juliani, Regina Célia Poli Frederico, Valéria Aparecida Bello, Carlos Eduardo Coral de Oliveira, Edna Maria Vissoci Reiche, Aline Vitali-Silva   +7 more
doaj   +1 more source

Propagation of spreading depression inversely correlates with cortical myelin content

, 2009
OBJECTIVE: Cortical myelin can be severely affected in patients with demyelinating disorders of the central nervous system. However, the functional implication of cortical demyelination remains elusive.
David Liebetanz, Paulus, Walter J., Glaser, R., Guedes, R., Paulus, W., Wolfgang Brück, Rubem C. A. Guedes, Doron Merkler, Sereda, Michael W., Brück, Wolfgang, Merkler, D., Brinkmann, Bastian G., Florian Klinker, Jürgens, T., Liebetanz, D., Walter Paulus, Tanja Jürgens, Stadelmann-Nessler, C., Bastian G. Brinkmann, Stadelmann-Nessler, Christine, Guedes, Rubem C. A., Brinkmann, B., Brueck, Wolfgang, Brück, W., Glaser, Raoul, Liebetanz, David, Sereda, M., Merkler, Doron, Paulus, Walter, Klinker, F., Raoul Glaser, Christine Stadelmann-Nessler, Juergens, Tanja, Jürgens, Tanja, Michael W. Sereda, Klinker, Florian   +35 more
core   +1 more source

NMDAR‐antibody encephalitis: Seizure semiology and EEG findings

Epileptic Disorders, EarlyView.
Abstract Background N‐methyl‐D‐aspartate receptor antibody encephalitis (NMDAR‐Ab‐E) is an autoantibody‐mediated disorder, characterized by acute development of neuropsychiatric symptoms, seizures, movement disorders, and autonomic instability. Objectives To describe acute seizure semiology and electroencephalogram (EEG) findings in patients with a ...
Maria Emilia C. Andraus, Bernard Liem, Sidra Aurangzeb, Mkael Symmonds, Adam E. Handel, Sarosh R. Irani, Arjune Sen   +6 more
wiley   +1 more source

Gabapentin Suppresses Cortical Spreading Depression Susceptibility

, 2010
Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Cav2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Cav2.1 through high ...
Ergin Dileköz, Chiho Kudo, Ulrike Hoffmann, Ayata, Cenk, Hoffmann, Ulrike, Dilekoz, ERGİN, Cenk Ayata, Kudo, Chiho   +7 more
core   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Modeling the Spreading Cortical Depression Wavefront

, 2002
Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2-5 mm/min and is followed by a 5-10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine.
Baysal, U, Haueisen, J, JENS HAUEISEN, UGUR BAYSAL   +3 more
core   +1 more source