Results 201 to 210 of about 10,427 (246)
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Modeling the Spreading Cortical Depression Wavefront
Annals of the New York Academy of Sciences, 2002Abstract: Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2–5 mm/min and is followed by a 5–10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain ...
Ugur, Baysal, Jens, Haueisen
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Cortical Discontinuity and Propagation of Spreading Depression
American Journal of Physiology-Legacy Content, 1955The transmissibility of spreading depression across a cut severing all layers of the cortex was investigated in preparations in which 3 weeks to 3 months was allowed for healing of such an injury. No unequivocal signs of transmission of the spreading depression across the scar were observed, although in some instances the scar was less than 0.1 mm ...
A, Van Harreveld +2 more
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Physiological studies of cortical spreading depression
Biological Reviews, 2006Cortical spreading depression (CSD) produces propagating waves of transient neuronal hyperexcitability followed by depression. CSD is initiated by K+ release following neuronal firing or electrical, mechanical or chemical stimuli. A triphasic (30-50 s) cortical potential transient accompanies localized transmembrane redistributions of K+, glutamate ...
Justin M, Smith +3 more
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Electrophysiological correlates of cortical spreading depression
Behavioral Biology, 1973Cortical steady potential shifts were recorded in both anesthetized and chronic rats during cortical spreading depression. Unilateral application of 12 or 25% KC1 evoked steady potential shifts not only in the hemisphere which received KC1 but also in the contralateral hemisphere.
T J, Crow, L, Petrinovich, T J, Carew
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A dipole model for Spreading Cortical Depression
Brain Topography, 1996Spreading Cortical Depression (SCD) is the hyper-excitation, followed by extreme suppression of spontaneous electrical activity in the cortex. This work models SCD propagation using current dipoles to represent excitable pyramidal cells. An area of cortex, either gyrus or sulcus, supporting SCD is represented by surface dipoles oriented perpendicular ...
N, Tepley, R S, Wijesinghe
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Chronic daily cortical spreading depressions suppress spreading depression susceptibility
Cephalalgia, 2011Background: Migraine is a disabling chronic episodic disorder. Attack frequency progressively increases in some patients. Incremental cortical excitability has been implicated as a mechanism underlying progression. Cortical spreading depression (CSD) is the electrophysiological event underlying migraine aura, and a headache trigger.
Eikermann-Haerter, Katharina +6 more
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Epigenetic chromatin modifications in the cortical spreading depression
Brain Research, 2010Preconditioning with Cortical Spreading Depression induces a sort of tolerance to a subsequent episode of ischemia. The mechanism of this tolerance is not clear. We studied if such treatment induces epigenetic chromatin modifications on the hemispheres of rats preconditioned by Cortical Spreading Depression.
Rana G. +5 more
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Excitation and depression of cortical neurones during spreading depression
Experimental Brain Research, 1971Variations in the excitability of individual cortical neurones during the invasion of spreading depression (SD) have been monitored by observing the alterations of spontaneous and L-glutamate-induced firing. Invasion of many neurones during SD is marked by a brief burst of firing which occurs concurrently with the onset of the negative slow ...
J W, Phillis, S, Ochs
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Cortical spreading depression and thirst☆
Physiology & Behavior, 1968Abstract Bilateral, but not unilateral, cortical spreading depression inhibited drinking of water, whether motivated by water deprivation or cholinergic brain stimulation. This inhibition of behavior does not appear to be specific to cholinergic mechanisms, thirst, or appetitive responding.
R LEVITT, B KRIKSTONE
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Cortical spreading depression: An enigma
The European Physical Journal Special Topics, 2007The brain is a complex organ with active components composed largely of neurons, glial cells, and blood vessels. There exists an enormous experimental and theoretical literature on the mechanisms involved in the functioning of the brain, but we still do not have a good understanding of how it works on a gross mechanistic level.
R. M. Miura, H. Huang, J. J. Wylie
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