Results 211 to 220 of about 30,052 (310)

Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression. [PDF]

J Headache Pain
Brugia F, Ivanov K, Aroviita A, Giniatullina R, Lehtonen M, Malm T, Savinainen J, Giniatullin R, Della Pietra A.   +8 more
europepmc   +1 more source

EHMTI-0324. Expression of high-mobility group box 1 in the cerebral cortex after cortical spreading depression [PDF]

, 2014
Tsubasa Takizawa, Mamoru Shibata, Yohei Kayama, Toshihiko Shimizu, H. Toriumi, Taeko Ebine, Anri Koh, Norihiro Suzuki   +7 more
openalex   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Somatosensory migraine auras evoked by bihemispheric cortical spreading depression events in human parietal cortex. [PDF]

J Cereb Blood Flow Metab
Gollion C, Christensen RH, Ashina H, Al-Khazali HM, Fisher PM, Amin FM, Lauritzen M, Ashina M.   +7 more
europepmc   +1 more source

Dynamics of Ionic Shifts in Cortical Spreading Depression [PDF]

, 2015
Rune Enger, Wannan Tang, Gry Fluge Vindedal, Vidar R. Jensen, P. Johannes Helm, Rolf Sprengel, Loren L. Looger, Erlend A. Nagelhus   +7 more
openalex   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation. [PDF]

J Headache Pain
Uzay B, Donmez-Demir B, Ozcan SY, Kocak EE, Yemisci M, Ozdemir YG, Dalkara T, Karatas H.   +7 more
europepmc   +1 more source

Resting Cerebrovascular Haemodynamics and Dynamic Assessment of Cerebrovascular Function in Polycystic Ovary Syndrome

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Despite an increased cerebrovascular disease risk, the impact of Polycystic Ovary Syndrome (PCOS) on cerebrovascular haemodynamics and function is unknown. This study characterised cerebrovascular haemodynamics and function in women with PCOS versus healthy controls. Design Case‐control study.
Cory T. Richards, Thomas D. Griffiths, Zoe H. Adams, Melissa E. Wright, Saajan Davies, Jack S. Talbot, Lauren Broad‐Thomas, Diego García Esteban, Jessica J. Steventon, Patrice Brassard, Kevin Murphy, Philip E. James, D. Aled Rees, Rachel N. Lord   +13 more
wiley   +1 more source

Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression

, 2008
David W. Busija, Ferenc Bari, Ferenc Domoki, Takashi Horiguchi, K SHIMIZU   +4 more
openalex   +1 more source