Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood-brain barrier. [PDF]
Pain, 2020 Most centrally-acting migraine preventive drugs suppress frequency and velocity of cortical spreading depression (CSD). The purpose of the current study was to determine how the new class of peripherally acting migraine preventive drug (i.e., the anti ...
Melo-Carrillo A +4 more
europepmc +2 more sources
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression. [PDF]
Glia, 2019 Cortical spreading depression (CSD) is a slowly propagating wave of depolarization of gray matter. This phenomenon is believed to underlie the migraine aura and similar waves of depolarization may exacerbate injury in a number of neurological disease ...
Rosic B +7 more
europepmc +2 more sources
A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model. [PDF]
PLoS Comput Biol, 2019 Cortical spreading depression (SD) is a spreading disruption of ionic homeostasis in the brain during which neurons experience complete and prolonged depolarizations.
Tuttle A, Riera Diaz J, Mori Y.
europepmc +2 more sources
Antioxidant extract counteracts the effects of aging on cortical spreading depression and oxidative stress in the brain cortex [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To investigate the effects of Murici extract on the brain excitability-dependent phenomenon known as cortical spreading depression (CSD) and on brain oxidative stress.
Mariana Séfora Bezerra Sousa +3 more
doaj +3 more sources
Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2. [PDF]
Sci Rep, 2018 Migraine is a highly prevalent, debilitating, episodic headache disorder affecting roughly 15% of the population. Familial hemiplegic migraine type 2 (FHM2) is a rare subtype of migraine caused by mutations in the ATP1A2 gene, encoding the α2 isoform of ...
Kros L, Lykke-Hartmann K, Khodakhah K.
europepmc +2 more sources
A CHRONIC PREPARATION FOR SPREADING CORTICAL DEPRESSION [PDF]
Journal of the Experimental Analysis of Behavior, 1964 Allen M. Schneider, Michael Behar
openalex +4 more sources
The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo. [PDF]
Sci Rep, 2018 The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-
Richter F +7 more
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Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats. [PDF]
Brain Sci, 2023 Braz AF +4 more
europepmc +3 more sources
Recurrent migraine aura-like symptoms in an elderly woman: symptomatic cortical spreading depression? [PDF]
BMJ Case Rep, 2021 Glössmann K +3 more
europepmc +3 more sources
Cortical spreading depression as a site of origin for migraine: Role of CGRP. [PDF]
Cephalalgia, 2019 Close LN +4 more
europepmc +2 more sources