Results 81 to 90 of about 188,082 (293)

Molecular imaging of serotonin degeneration in mild cognitive impairment

Neurobiology of Disease, 2017
Neuropathological and neuroimaging studies have consistently demonstrated degeneration of monoamine systems, especially the serotonin system, in normal aging and Alzheimer's disease. The evidence for degeneration of the serotonin system in mild cognitive
Gwenn S. Smith, Frederick S. Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J. Sodums, Christopher M. Marano, Cynthia A. Munro, Jason Brandt, Michael A. Kraut, Yun Zhou, Dean F. Wong, Clifford I. Workman   +12 more
doaj   +1 more source

Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum [PDF]

, 2014
Amyotrophic lateral sclerosis (ALS) and behavioural variant frontotemporal dementia (bvFTD) are multisystem neurodegenerative disorders that manifest overlapping cognitive, neuropsychiatric and motor features.
A Giordano, AE Renton, BR Brooks, C Dobson-Stone, C Habas, C Lomen-Hoerth, C Mottolese, C Wedderburn, Carol Dobson-Stone, CJ Mahoney, CJ O'Halloran, CJ Stoodley, CJ Stoodley, CJ Stoodley, CJ Stoodley, CM Clark, D Seok Yi, DJ Irwin, DM Mezzapesa, E Mioshi, E Mioshi, E Mioshi, E Sbardella, EC Lauterbach, Emma Devenney, F Begeti, FA Middleton, FM Krienen, Glenda M. Halliday, GM Ringholz, H Baillieux, H Yoshida, HJ Rosen, HJ Rosen, J Kassubek, J Phukan, J Senda, Jan Kassubek, JD Schmahmann, JD Schmahmann, JH Balsters, JL Chang, JL Whitwell, JL Whitwell, JL Whitwell, JLR Andersson, JM Cedarbaum, John B. Kwok, John R. Hodges, JR Burrell, JS Snowden, JX O'Reilly, K Rascovsky, KA Josephs, L Thivard, LT Takada, M Irish, M Neumann, Matthew C. Kiernan, MC Kiernan, Michael Hornberger, MJ Strong, MP Alexander, MR Turner, O Hardiman, P Lillo, P Lillo, P McColgan, R Villanueva, Rachel H. Tan, RM Kelly, SM Smith, SM Smith, T Kanda, TE Nichols, TH Bak, V Garibotto, WW Seeley, Y Zhang, Z Chen, Z Terpening   +80 more
core   +3 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Cortical blindness as severe neuro-ophthalmological manifestation of tuberous sclerosis complex

GMS Ophthalmology Cases, 2017
Patients with retinal lesions related to tuberous sclerous complex (TSC) commonly have no impairment of visual acuity. We present a case of a 1-year-old Hispanic girl with TSC in which bilateral cortical blindness is documented.
Ortiz Z., Alvaro I., Cárdenas, Pedro Luis, Escaf, Luis C., Peralta, Marcela   +3 more
doaj   +1 more source

Tau and atrophy: domain-specific relationships with cognition. [PDF]

, 2019
BackgroundLate-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains.
Alzheimer’s Disease Neuroimaging Initiative, Banks, Sarah J, Brewer, James B, Dale, Anders M, Digma, Leonardino A, Madsen, John R, Reas, Emilie T   +6 more
core  

Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy: A Review [PDF]

, 2017
open8siPeople with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive re- habilitation is employed as a remedial intervention in clinical settings, but research is limited and findings ...
Alderighi, Marzia, Bosco, Anna, Del Felice, Alessandra, Grisafi, Davide, Martinato, Matteo, Masiero, Stefano, Sander, Josemir W., Thompson, Pamela J.   +7 more
core   +2 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]

, 2018
Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S, Minzenberg, Michael J, Soosman, Steffan K, Yoon, Jong H   +3 more
core   +3 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Non-verbal sound processing in the primary progressive aphasias [PDF]

, 2010
Little is known about the processing of non-verbal sounds in the primary progressive aphasias. Here, we investigated the processing of complex non-verbal sounds in detail, in a consecutive series of 20 patients with primary progressive aphasia [12 with ...
Bamiou, D.-E., Crutch, S. J., Frost, C., Goll, J. C., Loo, J. H. Y., Rohrer, J. D., Warren, J. D.   +6 more
core