Results 141 to 150 of about 957,864 (297)

Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease

Journal of Parkinson’s Disease
Background Compensatory mechanisms in Parkinson's disease (PD) are thought to explain the temporal delay between the beginning of the neurodegenerative process and the appearance of clinical signs.
Roy Dayan, Atira S Bick, Caroline Weill, Max Bauer, Halen Baker Erdman, Zvi Israel, Hagai Bergman, Netta Levin, David Arkadir   +8 more
doaj   +1 more source

KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]

, 2018
The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G., Eastwood, Dan C., Holan, Lyndsey, Maunze, Brian, Mehra, Vatsal, Simpson, Matthew T., Venkatesh, Ishwariya, Wang, Zimei   +7 more
core   +1 more source

Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers, Teije H. van Prooije, Kirsten C.J. Kapteijns, Jack J.A. van Asten, Caterina Mariotti, Lidia Sarro, Anna Nigri, Marina Grisoli, Giulia Coarelli, Alexandra Durr, Tom Scheenen, Bart van de Warrenburg   +11 more
wiley   +1 more source

Capecitabine-induced leukoencephalopathy involving the bilateral corticospinal tracts

Journal of Radiology Case Reports, 2016
An 80 year old lady with a history of metastatic sigmoid carcinoma presented with expressive dysphasia and unsteady gait 4 days after commencement of adjuvant capecitabine chemotherapy. MRI demonstrated restricted diffusion and T2/FLAIR hyperintensity involving the course of the bilateral corticospinal tracts, the corpus callosum and the middle ...
Mark Bang-Wei, Tan, Louis Elliott, McAdory   +1 more
openaire   +2 more sources

Speech and Deep Brain Stimulation in Parkinson's Disease, Essential Tremor, and Dystonia: A Systematic Review and Meta‐analysis

Movement Disorders, EarlyView.
Abstract Deep brain stimulation (DBS) effectively treats motor symptoms in movement disorders but often compromises speech through incompletely defined mechanisms. We conducted a PROSPERO‐registered systematic review and meta‐analysis of publications through August 2024 (CRD42024527738).
Elina Tripoliti, Takashi Tsuboi, Michael T. Barbe, Mario Sousa, Julie Barkmeier‐Kraemer, Hannah Jergas, Gaia Arno, Nicole Buie, Mikayla Day, Petr Krýže, Jayson R. Nelson, Aaron E.L. Warren, Shervin Rahimpour, Jan Rusz, Paul Krack, Kristina Simonyan   +15 more
wiley   +1 more source

Simultaneous Acquisition of Magnetic Resonance Elastography (MRE) and Diffusion Tensor Imaging (DTI) Optimized for Human Brain

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Increase clinical acceptance of MRE and DTI by shortening the scan time by half and providing diffusive and mechanical property maps that are inherently co‐registered. This proof‐of‐concept study evaluates the simultaneous DTI‐MRE acquisition in the human brain and compares its results to conventional DTI and MRE measurements.
Shujun Lin, Bradley P. Sutton, Richard L. Magin, Aaron T. Anderson, Dieter Klatt   +4 more
wiley   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

Developmental Medicine &Child Neurology, EarlyView.
This case series describes infants born near term with periventricular hemorrhagic infarction (PVHI), highlighting seizures as a common early symptom. Neonatal complications during delivery and pro‐thrombotic genetic mutations were slightly more common. MRI‐classified involvement was predominantly in the caudate vein territory.
Aleksandra Zaykova, Jeroen Dudink, Floris Groenendaal, Maarten H. Lequin, Manon J.N.L. Benders, Maria Luisa Tataranno, Elise Roze   +6 more
wiley   +1 more source

Predictors of upper‐extremity motor outcomes after constraint‐induced therapy or bimanual training in children with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To systematically review the factors that predict changes in upper‐extremity motor function in response to constraint‐induced movement therapy (CIMT) or bimanual training in children with cerebral palsy (CP). Method The PubMed, Cochrane, Embase, Scopus, CINAHL, and PEDro databases were searched. Studies were included if predictor variables
Emmanuel Segnon Sogbossi, Esther C. Zannou, Eric Dossa, Charbelia Houessou, Todegnon Franck Assogba, Marie Longton, Gauthier Everard, Catherine Mercier   +7 more
wiley   +1 more source

Functional Reorganization of White Matter Supporting the Transhemispheric Mechanism of Mirror Therapy After Stroke: A Multimodal MRI Study

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Mirror therapy (MT) is an effective approach in stroke recovery, but its impact on subcortical neural reorganization remains unclear. Thus, we aimed to investigate the neuroplastic effects on white matter due to MT.
Li Ding, Kexu Zhang, Xu Wang, Shanbao Tong, Xiaoli Guo, Jie Jia   +5 more
doaj   +1 more source