Results 191 to 200 of about 516,590 (413)

Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone [PDF]

open access: yesarXiv
Due to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW).
arxiv  

A catchment-based study of endocrine disruption in surface waters: multivariate evaluation of the health of a sentinel fish species exposed to sewage treatment works effluent [PDF]

open access: yes, 2009
Summary of the results in the context of EDCAT 5 project aims: 1. By comparing appropriate biomarkers in fish sampled from STW-impacted sites and control sites during the pre-remediation period, to determine whether there was evidence for any effects ...
Abel, David   +6 more
core  

Refractory nummular eczema in child successfully treated with NB‐UVB and topical delgocitinib

open access: yes, 2022
Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 229-230, December 2022.
Ichiro Kurokawa, Jun‐Ichiro Ono
wiley   +1 more source

Addressing recent challenges in isotope ratio mass spectrometry: Development of a method applicable to 1‐androstene‐steroids, 6α‐hydroxy‐androstenedione, and androstatrienedione

open access: yesDrug Testing and Analysis, Volume 14, Issue 11-12, Page 1891-1903, November-December 2022., 2022
A method to determine the carbon isotope ratios of nine potentially pseudo‐endogenous steroids relevant to sports drug testing was developed and validated. Using established gas chromatography/combustion/isotope ratio mass spectrometry instrumentation, limits of quantification were determined at 10 ng/ml for a 20 ml urine aliquot for all analytes ...
Thomas Piper, Mario Thevis
wiley   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler   +34 more
wiley   +1 more source

Estimation of Corticosteroid Metabolites in Urine. [PDF]

open access: bronze, 1956
Lars Plantin   +4 more
openalex   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

open access: yesArthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava   +9 more
wiley   +1 more source

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