Lysine-Cysteine-Serine-Tryptophan Inserted into the DNA-Binding Domain of Human Mineralocorticoid Receptor Increases Transcriptional Activation by Aldosterone [PDF]
Due to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs differ by only four amino acids, Lys,Cys,Ser,Trp (KCSW).
arxiv
Corticosteroid secretion by the autotransplanted adrenal gland of the conscious sheep [PDF]
Ian R. McDonald, Magda Reich
openalex +1 more source
A catchment-based study of endocrine disruption in surface waters: multivariate evaluation of the health of a sentinel fish species exposed to sewage treatment works effluent [PDF]
Summary of the results in the context of EDCAT 5 project aims: 1. By comparing appropriate biomarkers in fish sampled from STW-impacted sites and control sites during the pre-remediation period, to determine whether there was evidence for any effects ...
Abel, David+6 more
core
Refractory nummular eczema in child successfully treated with NB‐UVB and topical delgocitinib
Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 229-230, December 2022.
Ichiro Kurokawa, Jun‐Ichiro Ono
wiley +1 more source
A method to determine the carbon isotope ratios of nine potentially pseudo‐endogenous steroids relevant to sports drug testing was developed and validated. Using established gas chromatography/combustion/isotope ratio mass spectrometry instrumentation, limits of quantification were determined at 10 ng/ml for a 20 ml urine aliquot for all analytes ...
Thomas Piper, Mario Thevis
wiley +1 more source
Desensitization of a Nurse to Streptomycin under Corticosteroid Cover [PDF]
A. Pines
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Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler+34 more
wiley +1 more source
Estimation of Corticosteroid Metabolites in Urine. [PDF]
Lars Plantin+4 more
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Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava+9 more
wiley +1 more source
Corticosteroids in Treatment of Skin Diseases: I. Systemic Treatment [PDF]
F. R. Bettley
openalex +1 more source