Results 211 to 220 of about 469,630 (315)

Short versus long corticosteroid therapy for immune checkpoint inhibitors-induced acute tubulointerstitial nephritis. [PDF]

Clin Kidney J
Auñón P, Lopes V, Minguez I, Pérez-Romero P, Peña-Ordónez K, Serrano-Soto M, Rivera M, Alonso F, Mercado VR, Moliz C, Cabello V, Morales E, Gutiérrez E, Cavero T.   +13 more
europepmc   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts. [PDF]

Children (Basel)
Plessas-Azurduy P, Lapointe A, Wutthigate P, Spénard S, Villeneuve A, Hébert A, Shany E, Richardson J, Geva N, Mawad W, Cavallé-Garrido T, Beltempo M, Shalish W, Sant'Anna G, Altit G.   +14 more
europepmc   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Corticosteroids as adjunctive therapy in acute meningitis: a narrative review. [PDF]

Ann Med Surg (Lond)
Ullah N, Khan K, Haseeb A, Ahmad Z, Abbas SH, Samad M, Safdar S, Qayyum SN, Khan R, Noori S.   +9 more
europepmc   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Impact of systemic steroids on asthma biomarkers: A comprehensive analysis. [PDF]

World Allergy Organ J
Paoletti G, Costanzo G, Marchetti M, Valentini G, Scardini A, Sambugaro G, Bullita M, Vassallo S, Giovanni Ledda A, Firinu D, Walter Canonica G, Del Giacco S, Heffler E, Anna Maria Luigia Costanzo G.   +13 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

New Cortisol Thresholds for the Diagnosis of Adrenal Insufficiency Using the Low-Dose Synacthen Test in Children on Long-Term Corticosteroids: A North African Pilot Study. [PDF]

Diagnostics (Basel)
Ach T, Marwa A, Wiem BHA, Hajer M, Saafi W, Oumayma Z, Amel T, Raoudha K, Nesrine J, Jihene B, Najla S, El Fekih H, Ghada S, Wided D, Zaouali M, Hasni Y, Lamia B.   +16 more
europepmc   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source