Results 51 to 60 of about 342,940 (312)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Antioxidant activity of rat liver with a low resistance to hypoxia after systemic ischemia reperfusion

Russian Open Medical Journal, 2021
Objective — To assess the antioxidant activity of rat liver after systemic ischemia reperfusion (IRP). Material and Methods — The study was conducted on 70 male rats. For all animals of the treatment group (n=35) under ether anesthesia, we were stopping
Gulnar A. Bayburina, Elena A. Nurgaleeva, Ajgul F. Samigullina, Ekaterina R. Farshatova, Timur I. Ganeev, Eduard F. Agletdinov, Tatyana V. Tarasova   +6 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study

Emerging Microbes and Infections, 2020
Critically ill patients with coronavirus diseases 2019 (COVID-19) are of grave concern. Those patients usually underwent a stage of excessive inflammation before developing acute respiratory distress syndrome.
Yang Li, Xian Zhou, Tao Li, Shiji Chan, Yiqi Yu, Jing-Wen Ai, Haocheng Zhang, Feng Sun, Qiran Zhang, Lei Zhu, Lingyun Shao, Bin Xu, Wenhong Zhang   +12 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Rapid successful management of diffuse alveolar hemorrhage as the primary presentation of chlorine gas inhalation; A rare case report

Acta Medica Iranica, 2021
Chlorine-containing bleach, as a common disinfectant, can cause mild to severe symptoms from nasal irritation to life-threatening conditions such as acute respiratory distress syndrome (ARDS).
samaneh kakhki, Mohsen Yaghubi, Morteza Valaei, Reza Ghasemi, Mahmood Hosseinzadeh Maleki, Sara Rezaei   +5 more
doaj   +1 more source

The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial.

, 2014
OBJECTIVES: Vasopressin and corticosteroids are both commonly used adjunctive therapies in septic shock. Retrospective analyses have suggested that there may be an interaction between these drugs, with higher circulating vasopressin levels and improved ...
Terblanche, Marius, Perkins, Gavin D., Brett, Stephen J., Gordon, Anthony C., Perkins, Gavin D, Stotz, Martin, Ashby, Deborah, Brett, Stephen J, Mason, Alexina J., Mason, Alexina J, Gordon, Anthony C   +10 more
core   +1 more source

Effect of corticosteroids and long-acting ß2- agonists in a human cell culture based "in vitro" model of airway inflammation and tissue remodeling [PDF]

, 2006
Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation and remodeling. In non-pathological conditions tissue homeostasis is maintained by the balance between extracellular matrix (ECM) synthesis and ...
Goulet, Stéphanie
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluation of corticosteroid use pattern and their adverse effects in patients visiting the dermatology department of a tertiary care teaching hospital in Warangal, India

MGM Journal of Medical Sciences, 2021
Introduction: Corticosteroids have become a mainstay of pharmacotherapy in dermatology because of their anti-inflammatory and immunosuppressive properties.
Gogula Archana Reddy, Samreen Ayesha, Masood Ali Sheema, Bandaru Sheshagiri Sharvana Bhava, Valupadas Chandrashekar, Eggadi Venkateshwarlu   +5 more
doaj   +1 more source