Results 91 to 100 of about 96,764 (277)
PLoS ONE, 2021 Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity for
José Gulfo +7 more
doaj +1 more source
Wellbeing of Alcohol-preferring Rats Euthanized with Carbon Dioxide at Very Low and Low Volume Displacement Rates [PDF]
, 2019 The 2013 AVMA Guidelines on Euthanasia recommend the use of very-low or low flow rates of 100% carbon dioxide to euthanize small rodents. Although inhalation of high concentrations of carbon dioxide are generally recognized as painful in humans, whether ...
Hickman, Debra L.
core +1 more source
Measurement of corticosterone in mice: a protocol for a mapping review [PDF]
Laboratory Animals, 2019 Severity assessment for experiments conducted with laboratory animals is still based mainly on subjective evaluations; evidence-based methods are scarce. Objective measures, amongst which determination of the concentrations of stress hormones, can be used to aid severity assessment.
Leenaars, Cathalijn H C +13 more
openaire +6 more sources
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, EarlyView.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Research Note: Quantifying corticosterone in turkey (Meleagris gallopavo) feathers using ELISA
Poultry Science, 2020 The measurement of corticosterone in feathers is an appealing tool for assessing glucocorticoids in wild and domestic bird species. Feather corticosterone measurements can be performed noninvasively and can provide a means for comparing glucocorticoid ...
Emily M. Leishman +6 more
doaj +1 more source
Unveiling sleep disturbances in KCNB1‐related disorders: Insights from a cohort of 78 individuals
Epilepsia Open, EarlyView.Abstract Objectives Sleep disturbances are frequent comorbidities in epilepsies and developmental encephalopathies. This study aimed to characterize sleep abnormalities in individuals with KCNB1‐related disorders, focusing on their prevalence, clinical manifestations, and impact on daily functioning.
Giovanna Scorrano +4 more
wiley +1 more source
Frontiers in Neuroscience, 2013 Previous studies have primarily interpreted gene expression regulation by glucocorticoids in the brain in terms of impact on neurons; however, less is known about the corresponding impact of glucocorticoids on glia and specifically astrocytes in vivo ...
Bradley S. Carter +5 more
doaj +1 more source
Chronic Stress, 2020 Background There are no data on the effect of exogenous corticosterone on depressive-like behavior in juvenile rats. Furthermore, it has not been tested whether the effects of corticosterone in female rats is different before or after puberty.
Tyler R. Nickle +2 more
doaj +1 more source
The Role of Corticosterone Rhythmicity in Puberty [PDF]
Biology of Reproduction, 1976 To establish the functional importance of a peripheral rhythm of corticosterone in the timing of the onset of vaginal opening and ovulation, rats were adrenalectomized at 22 days of age and maintained on either saline or corticosterone (B) dissolved in their drinking water.
openaire +2 more sources