Results 91 to 100 of about 43,220 (248)

One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin‐Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin‐Requiring Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin‐treated type 2 diabetes (T2D), but the durability of this effect and the impact of repeated SSTR2a dosing on overall glycaemia in T2D are unclear.
Ninoschka C. D'Souza, Emily G. Hoffman, Sara C. Atherley, Sabrina Champsi, Nadia Aleali, Richard T. Liggins, Owen Chan, Michael C. Riddell   +7 more
wiley   +1 more source

Why we Should Study Solitary Species to Understand the Costs of Group‐Living

Ethology, EarlyView.
It's easier to measure the benefits than the costs of a trait. Solitary species benefit by avoiding the costs of group living. Thus, measuring benefits of solitary living informs us about the costs of group living. ABSTRACT While for decades behavioral ecologists have studied the benefits of group living, measuring its costs has been more difficult. It
Lindelani Makuya, Carsten Schradin
wiley   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

THE METABOLISM OF CORTICOSTERONE IN MAN [PDF]

Journal of Clinical Investigation, 1960
R E, PETERSON, C E, PIERCE
openaire   +2 more sources

Life‐stage variation in Sable Shearwater (Ardenna carneipes) physiology assessed using proteomics

Ibis, EarlyView.
Life‐stage transitions in seabirds involve substantial shifts in physiological demands, yet the molecular mechanisms underpinning these changes remain poorly resolved. Here we applied untargeted data‐independent acquisition mass spectrometry (DIA‐MS) to characterize and compare the plasma proteomes of fledgling and adult Sable Shearwaters Ardenna ...
Alix M. de Jersey, Alexander L. Bond, Richard Wilson, Graeme R. Zosky, Jack Rivers‐Auty, Jennifer L. Lavers   +5 more
wiley   +1 more source

Expression of corticoid‐regulatory genes in the gills of Atlantic salmon (Salmo salar) parr and smolt and during salinity acclimation

Journal of Fish Biology, EarlyView.
Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe, Takashi Yada, Graham Young, Amy M. Regish, Stephen D. McCormick   +4 more
wiley   +1 more source

Circadian Corticosterone Profile in Laying Hens (Gallus gallus domesticus)

Animals
Measurement of blood corticosterone concentrations has been established as an indicator for assessment of acute distress. Therefore, knowledge on physiological fluctuations is required, but previous studies allow little conclusion on daily fluctuations ...
Theresa Hillebrecht, Rüdiger Korbel, Monika Rinder, Manfred Gahr   +3 more
doaj   +1 more source

Dietary L‐Tyrosine Sustains Egg Production and Quality by Modulating Promoter CpG Methylation, Gene Expression, and Hormone Profiles in Reproductive Signalling Pathways of Aged Laying Hens

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Managing prolactin (PRL)‐mediated reproductive suppression is critical for maintaining egg production in commercial laying hens. L‐tyrosine (TYR), a precursor of dopamine (DA), may counteract age‐related reproductive decline by suppressing PRL, thereby sustaining productivity and egg quality in late‐phase laying hens.
Hasan Hüseyin İpçak
wiley   +1 more source

The Protective Effects of Polygala tenuifolia and Tenuifolin on Corticosterone-Evoked Ferroptosis, Oxidative Stress, and Neuroinflammation: Insights from Molecular Dynamics Simulations and In Vitro Experiments

Foods
Excessive stress is a well-established contributor to neurological damage, insomnia, and depression, imposing a significant burden on individuals and society. This underscores the urgent need for effective stress-relief strategies.
Chaoyi Xue, Zhiyong He, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Fang Qin, Mingmin Chen, Hui Ye, Jie Chen   +8 more
doaj   +1 more source

Do fawn‐footed mosaic‐tailed rats experience age‐related cognitive decline in novel object recognition?

Journal of Zoology, EarlyView.
We explored age‐related cognitive decline in captive fawn‐footed mosaic‐tailed rats (Melomys cervinipes) using a novel object recognition task. Contrary to expectations, recognition memory did not decline with age, but recognition memory was lower in intermediate‐aged rats compared to both older and younger individuals.
K. DiBenedetto, M. K. Rowell, T. L. Rymer   +2 more
wiley   +1 more source