Results 81 to 90 of about 138,058 (298)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Xiao Yao San mitigates corticosterone stimulation-induced hippocampal neuronal damage by inhibiting GR phosphorylation and nuclear translocation via FKBP4 involvement

BMC Complementary Medicine and Therapies
Background Corticosterone stimulation has profound physiological and neurological effects on individuals, necessitating effective interventions to mitigate its impact. Current therapeutic approaches for corticosterone stimulation injury have limitations,
Xuedi Kang, Ting Wang, Haiping Wan, Wenjun Fu, Songjun Lin   +4 more
doaj   +1 more source

Consequences of the Lack of IL-10 in Different Endotoxin Effects and its Relationship With Glucocorticoids [PDF]

, 2019
Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a ...
Barrientos, Gabriela Laura, Córdoba Moreno, Marlina Olyissa, Fontanals, Adriana Mirta, Isturiz, Martín Amadeo, Montagna, Daniela Romina, Pineda, Gonzalo Ezequiel, Ramos, Maria Victoria, Rearte, María Bárbara, Toblli, Jorge Eduardo, Todero, Maria Florencia, Yokobori, Noemí   +10 more
core   +1 more source

Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

Journal of Neuroscience, 1997
It is well known that the hypothalamo-pituitary-adrenal (HPA) axis is altered by early environmental experiences, particularly in the perinatal period.
M. Vallée, W. Mayo, F. Dellu, M. Le Moal, H. Simon, S. Maccari   +5 more
semanticscholar   +1 more source

Electroacupuncture reshapes the microbial co‐occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease

iMetaOmics, EarlyView.
Microbial keystone species and gut microbiota composition are highly variable during the pathological development of the behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). Age stratification reveals stage‐specific gut microbial signatures in AD‐related BPSD.
Fu‐You Su, Chia‐Min Lin, Chao Liu, Yiqin Yao, Hui Wang, Chunxue Zhang, Wei Yi, Nenggui Xu   +7 more
wiley   +1 more source

Sustained corticosterone rise in the prefrontal cortex is a key factor for chronic stress-induced working memory deficits in mice

Neurobiology of Stress, 2019
Exposure to prolonged, unpredictable stress leads to glucocorticoids-mediated long-lasting neuroendocrine abnormalities associated with emotional and cognitive impairments.
Gaelle Dominguez, Nadia Henkous, Thomas Prevot, Vincent David, Jean-Louis Guillou, Catherine Belzung, Nicole Mons, Daniel Béracochéa   +7 more
doaj   +1 more source

Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus.

PLoS ONE, 2021
Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity for
José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Grasa   +7 more
doaj   +1 more source

Wellbeing of Alcohol-preferring Rats Euthanized with Carbon Dioxide at Very Low and Low Volume Displacement Rates [PDF]

, 2019
The 2013 AVMA Guidelines on Euthanasia recommend the use of very-low or low flow rates of 100% carbon dioxide to euthanize small rodents. Although inhalation of high concentrations of carbon dioxide are generally recognized as painful in humans, whether ...
Hickman, Debra L.
core   +1 more source

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation

iMetaOmics, EarlyView.
Microbiota‐gut‐brain axis multiorgan chip and its applications in drug evaluation. The chip includes essential biological components such as gut microbiota, gut barrier, blood‐brain barrier (BBB), and brain. This integrated platform incorporates neural (blue), endocrine (yellow), immune (pink), and metabolic (green) pathways to investigate the impact ...
Yue Tang, Hewen Chen, Ziyue Zhao, Xuesong Kang, Wenxin Wang, Kun Dai, Yufei Guo, Axin Liang, Aiqin Luo, Zikai Hao   +9 more
wiley   +1 more source

Stress response of fire salamander larvae differs between habitat types

Royal Society Open Science
The larvae of the European fire salamander (Salamandra salamandra) can inhabit two different habitats: streams and ponds. Streams are characterized by lower predation risks and higher food availability. Thus, ponds are considered a less suitable habitat.
Laura Schulte, Pia Oswald, Max Mühlenhaupt, Edith Ossendorf, Sabine Kruse, Sylvia Kaiser, Barbara A. Caspers   +6 more
doaj   +1 more source