BackgroundCis, cis-muconic acid (MA) is a dicarboxylic acid of recognized industrial value. It provides direct access to adipic acid and terephthalic acid, prominent monomers of commercial plastics.ResultsIn the present work, we engineered the soil ...
Judith Becker +4 more
semanticscholar +1 more source
Enzymatic and microbial routes to bioplastics: The green chemistry frontier of biopolymers
Microbial biosynthesis and engineered enzyme platforms are expanding the design space of polyhydroxyalkanoate bioplastics. By combining fermentation, PHA synthase engineering and cell‐free modular systems, tailored biodegradable polymers can be produced with tunable properties, supporting more sustainable materials and future circular bioeconomy ...
Giovanni Gallo +4 more
wiley +1 more source
Systematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
Background l-Ornithine is a non-protein amino acid with extensive applications in medicine and the food industry. Currently, l-ornithine production is based on microbial fermentation, and few microbes are used for producing l-ornithine owing to ...
Bin Zhang +4 more
doaj +1 more source
Chassis organism from Corynebacterium glutamicum: the way towards biotechnological domestication of Corynebacteria. [PDF]
For a long time, Corynebacteria have been the organisms of choice for industrial bioproduction of amino acids. Later on, Corynebacteria have also been used for making biofuels and a suite of added-value chemicals.
Lorenzo, Víctor de
core +1 more source
Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen +6 more
wiley +1 more source
Identifying the Growth Modulon of Corynebacterium glutamicum [PDF]
The growth rate (μ) of industrially relevant microbes, such as Corynebacterium glutamicum, is a fundamental property that indicates its production capacity. Therefore, understanding the mechanism underlying the growth rate is imperative for improving productivity and performance through metabolic engineering.
Thorsten Haas +8 more
openaire +5 more sources
Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum
Shikimate is a key high-demand metabolite for synthesizing valuable antiviral drugs, such as the anti-influenza drug, oseltamivir (Tamiflu). Microbial-based strategies for shikimate production have been developed to overcome the unstable and expensive supply of shikimate derived from traditional plant extraction processes.
Park, Eunhwi +6 more
openaire +3 more sources
The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress [PDF]
Mycothiol (MSH) is the major low molecular weight (LMW) thiol in Actinomycetes and functions in post-translational thiol-modification by protein S-mycothiolation as emerging thiol-protection and redox-regulatory mechanism.
Adrian, Lorenz +14 more
core +1 more source
Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine-carboxylic acid) is formed in various bacteria as a cell protectant against all kinds of stress. Its preservative and protective effects on proteins, cells, and tissues have enabled various applications ...
Gideon Gießelmann +12 more
semanticscholar +1 more source
Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source

