Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi +6 more
wiley +1 more source
A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis [PDF]
Background: Bacterial exported proteins represent key components of the host-pathogen interplay. Hence, we sought to implement a combined approach for characterizing the entire exoproteome of the pathogenic bacterium Corynebacterium pseudotuberculosis,
Pimenta, Adriano M. C. +59 more
core +1 more source
Advances in large DNA fragment assembly for microbial cell factory engineering
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang +5 more
wiley +1 more source
Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors [PDF]
Trost E, Al-Dilaimi A, Papavasiliou P, et al. Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors. BMC Genomics.
Viehöver, Prisca +59 more
core +2 more sources
Systematic pathway engineering of Corynebacterium glutamicum S9114 for l-ornithine production
Background l-Ornithine is a non-protein amino acid with extensive applications in medicine and the food industry. Currently, l-ornithine production is based on microbial fermentation, and few microbes are used for producing l-ornithine owing to ...
Bin Zhang +4 more
doaj +1 more source
ABSTRACT Amylosucrase (ASase, E.C. 2.4.1.4) is a transglucosidase that catalyzes α‐glucan synthesis and transglycosylation reactions using sucrose as the sole substrate. Unlike Leloir glycosyltransferases requiring expensive nucleotide sugars, ASases utilize readily available sucrose as a cost‐effective glucose donor, offering economic advantages for ...
Dong‐Ho Seo +2 more
wiley +1 more source
Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms [PDF]
Baumbach J, Rahmann S, Tauch A. Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms. BMC Systems Biology.
Sven Rahmann +5 more
core +1 more source
Accelerated Adaptive Evolution of Gram‐Negative Bacteria With a Broad‐Host‐Range Dual Base Editor
We developed a broad‐host‐range dual base editor that transiently induces genome‐wide hypermutation, accelerating adaptive laboratory evolution by up to four orders of magnitude. The platform rapidly generates improved bacterial phenotypes across diverse Gram‐negative species, enabling faster evolutionary engineering for biotechnology.
Tomas Aparicio +4 more
wiley +1 more source
Due to the non-renewable nature of fossil fuels, microbial fermentation is considered a sustainable approach for chemical production using glucose, xylose, menthol, and other complex carbon sources represented by lignocellulosic biomass.
Bin Zhang +9 more
doaj +1 more source
Cryo‐EM structures of multiple‐peptide resistance factor (MprF) from Pseudomonas aeruginosa
Multiple peptide resistance factor (MprF) is a bacterial enzyme that carries out the aminoacylation of lipid head groups. CryoEM analysis of MprF from Pseudomonas aeruginosa reveals a dimeric enzyme, distinct from its homologues in Rhizobium. The soluble GNAT domain contains a dynamic amphipathic helix (TTH) that adopts different positions in detergent
Shaileshanand Jha, Kutti R. Vinothkumar
wiley +1 more source

