Results 131 to 140 of about 167,854 (304)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Comparing Absorbable and Nonabsorbable Sutures in Corporeal Plication for Treatment of Congenital Penile Curvature

Urology Journal, 2011
PURPOSE: To compare the outcome of corporeal plication using absorbable versus nonabsorbable sutures for the treatment of congenital penile curvature.MATERIALS AND METHODS: Thirty-eight men older than 15 years old with congenital penile curvature were ...
Abbas Basiri, Reza Sarhangnejad, Seyyed Mohammad Ghahestani, Mohammad Hadi Radfar   +3 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Promosi Melalui Endorse Pada Produk Kosmetik Wardah Ditinjau Dari Perspektif Bisnis Syariah (Studi Kasus Pada Mahasiswa Fakultas Ekonomi dan Bisnis Islam UIN Fatmawati Sukarno Bengkulu)

Al-Intaj
This study aims to  determine promotion through endorsement in increasing consumer buying interest in wardah cosmetic products and the application of sharia business principles in the promotion of endorsement on wardah cosmetic products.
Yeka Effrianti, Eka Sri Wahyuni
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

F-theorem, duality and SUSY breaking in one-adjoint Chern-Simons-Matter theories

, 2012
We extend previous work on N=2 Chern-Simons theories coupled to a single adjoint chiral superfield using localization techniques and the F-maximization principle.
Affleck, Affleck, Aganagic, Amariti, Amariti, Benini, Benvenuti, Bhattacharya, Casini, Cheon, Dolan, Gabella, Gadde, Gaiotto, Ginsparg, Giveon, Gulotta, Halmagyi, Hama, Herzog, Hwang, Imamura, Intriligator, Intriligator, Jafferis, Jafferis, Jafferis, Kapustin, Kapustin, Kapustin, Kapustin, Kinney, Klebanov, Krattenthaler, Kutasov, Kutasov, Marino, Marino, Marino, Marino, Marino, Marino, Martelli, Minwalla, Myers, Myers, Niarchos, Niarchos, Niarchos, Pasquetti, Pestun, Rains, Romelsberger, Spiridonov, Spiridonov, Spiridonov, Takeshi Morita, Vasilis Niarchos, Willett, Witten, Witten, Zamolodchikov   +61 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Mitigating facial nerve injury risks in aesthetic surgery: A narrative review of surgical practices and anatomicsal challenges

JPRAS Open
Facial nerve injuries pose challenges in cosmetic surgery. We comprehensively reviewed the anatomy of the facial nerve, with a focus on its five major branches—temporal, zygomatic, buccal, marginal mandibular, and cervical— and explored the clinical ...
Abdallah Abushehab, Sean Huu-Tien Nguyen, Jordan Sauve, Pravin Meshram, Daniah ALNafisee, Victor Vakayil, Warren Schubert, Raeesa Kabir, Neej Patel, Andrew Fazio, Anthony J Weinhaus, James Harmon, Jr.   +11 more
doaj   +1 more source

Medicalization of Female Beauty: A Content Analysis of Cosmetic Procedures [PDF]

, 2013
Over the past decade, cosmetic procedures have significantly increased in options available for females to achieve the American cultural standards of beauty.
King, Keith K., Merianos, Ashley L., Vidourek, Rebecca A.   +2 more
core   +1 more source