Results 111 to 120 of about 64,617 (246)

In silico tools and transcriptomics analyses in the mutagenicity assessment of cosmetic ingredients: a proof-of-principle on how to add weight to the evidence.

, 2016
<p>Prior to the downstream development of chemical substances, including pharmaceuticals and cosmetics, their influence on the genetic apparatus has to be tested. Several in vitro and in vivo assays have been developed to test for genotoxicity.
G. Ates, B. Mertens, A. Roncaglioni, E. Benfenati, T.Y. Doktorova, C. Chesne, D. Milushev, P. Vanparys, V. Rogiers, G. Raitano, M. Van Bossuyt, A. Heymans   +11 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Proof of Concept: Home Self‐Monitoring of Atopic Skin State Toward Better Emollient Compliance

Dermatologic Therapy
Atopic dermatitis (AD) is a high‐burden disease for patients. Regular application of emollients is a prophylactic measure for maintaining a more functional skin barrier.
J. Le Digabel, C. Lauze, J. Filiol, R. Marinescu, S. Alvarez-Georges, V. Mengeaud, G. Josse   +6 more
doaj   +1 more source

Research Advances on the Release Mechanism and Regulation Technology of Food Aromas Based on Interface Chemistry

Shipin gongye ke-ji
Aroma was a key determinant of food quality and a major driver of consumer preference. The release of aroma compounds occurs across complex multiphase interfaces. Understanding the interactions between food interfaces and aromas was therefore crucial for
Zizheng LI, Xin HUANG, Yunchong ZHANG, Qinfei KE, Xingran KOU   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Formulation and Function of Cosmetics

, 1970
xiii;586hal ...
Fenton, G.L.
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Prospective, Randomized, Double‐Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population

Health Science Reports
Background and Aims Asian skin is more sensitive than Caucasian. When it comes to anti‐aging treatments, some classic actives like Retinoids, are not friendly to Asian skin due to irritation issues.
Xuefang Shi, Yimeng Wang, Huihui Zhang, Tao Zhang   +3 more
doaj   +1 more source