Results 91 to 100 of about 279,066 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Protective Properties of Botanical Extracts against 5G Radiation-induced Damage to Human Skin, as Demonstrated in Preliminary Data from a Keratinocyte Cell Culture Model

Frontiers in Bioscience-Landmark
Background: Next-generation 5G communication technology involves increasing use of 3–100 GHz wireless bands in population centers. Though still non-ionizing, this implies higher radiation energy vs. existing bands. The range is also shorter, needing more
Fabien Havas, Moshe Cohen, Shlomo Krispin, Joan Attia-Vigneau   +3 more
doaj   +1 more source

Tobramycin Promotes Melanogenesis by Upregulating p38 MAPK Protein Phosphorylation in B16F10 Melanoma Cells

Antibiotics, 2019
Tobramycin is an aminoglycoside-based natural antibiotic derived from Streptomyces tenebrarius, which is primarily used for Gram-negative bacterial infection treatment.
Seung-Hyun Moon, You Chul Chung, Chang-Gu Hyun   +2 more
doaj   +1 more source

Print Advertising In The Us And Hong Kong: A Comparative Analysis [PDF]

Given the static condition of the global economy marketers are cutting advertising budgets commensurate with dismal sales. It is a longstanding belief that utilizing a standardized advertising approach not only controls good ideas and provides for a ...
Ka Man Carman CHU, Nabil RAZZOUK, Olesia LUPU, Victoria Ann SEITZ   +3 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Clinical profiling of skin microbiome and metabolome during re-epithelialization

Scientific Reports
We investigated changes in skin microbiome and metabolome linked to wound healing and how these are affected by a formula known to improve re-epithelialization.
P. Bianchi, C. Jacques, J. Theunis, E. L. Jamin, C. Orlandi, L. Cauhape, S. Alvarez-Georges, A. Alves, A. Simcic-Mori, C. Lauze, E. Gravier, F. Carballido, V. Ribet, S. Bessou-Touya, H. Duplan   +14 more
doaj   +1 more source

Anti-UV Microgel Based on Interfacial Polymerization to Decrease Skin Irritation of High Permeability UV Absorber Ethylhexyl Methoxycinnamate

Gels
Ethylhexyl methoxycinnamate (EHMC) is frequently employed as a photoprotective agent in sunscreen formulations. EHMC has been found to potentially contribute to health complications as a result of its propensity to produce irritation and permeate the ...
Wei Wang, Qi-Tong He, Yin-Feng Chen, Bai-Hui Wang, Wen-Ying Xu, Qing-Lei Liu, Hui-Min Liu   +6 more
doaj   +1 more source

A Role for Contrast Gain Control in Skin Appearance [PDF]

, 2019
Apparent contrast can be suppressed or enhanced when presented within surrounding images. This contextual modulation is typically accounted for with models of contrast gain control.
Batres, Carlota, Jones, Alex L., Porcheron, Aurélie, Russell, Richard   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source