Results 71 to 80 of about 34,734 (271)

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Search for the Gravitational-wave Background from Cosmic Strings with the Parkes Pulsar Timing Array Second Data Release

The Astrophysical Journal, 2022
We perform a direct search for an isotropic stochastic gravitational-wave background (SGWB) produced by cosmic strings in the Parkes Pulsar Timing Array (PPTA) Data Release 2 (DR2).
Zu-Cheng Chen, Yu-Mei Wu, Qing-Guo Huang
doaj   +1 more source

Biased-estimations of the Variance and Skewness

, 1998
Nonlinear combinations of direct observables are often used to estimate quantities of theoretical interest. Without sufficient caution, this could lead to biased estimations.
Baugh C. M., Baugh C. M., Bernardeau F., Bernardeau F., Colombi S., Dalton G. B., Efstathiou G., Gaztanaga E., Gaztanaga E., Kaiser N., Kerscher M.   +10 more
core   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Small $E_8$ Instantons and Tensionless Non-critical Strings [PDF]

, 1996
T-duality is used to extract information on an instanton of zero size in the $E_8\times E_8$ heterotic string. We discuss the possibility of the appearance of a tensionless anti-self-dual non-critical string through an implementation of the mechanism ...
Amihay Hanany, Antoniadis, Becker, Cadavid, Callan, Callan, Callan, Duff, Duff, Gamboa, Gamboa, Ginsparg, Hořava, Isberg, Ori J. Ganor, Polchinski, Polchinski, Polchinski, Seiberg, Seiberg, Strominger, Strominger, Sundborg, Witten, Witten, Witten, Witten, Witten, Witten   +28 more
core   +2 more sources

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

WIYN Open Cluster Study. XXXIX. Abundances in NGC 6253 from HYDRA Spectroscopy of the Li 6708 A Region

, 2010
High-dispersion spectra of 89 potential members of the old, super-metal-rich open cluster, NGC 6253, have been obtained with the HYDRA multi-object spectrograph.
Anthony-Twarog, Anthony-Twarog, Anthony-Twarog, Arce, Barbara J. Anthony-Twarog, Bedin, Boesgaard, Boesgaard, Bragaglia, Bragaglia, Bruce A. Twarog, Carney, Carraro, Carretta, Chen, Cohen, Constantine P. Deliyannis, Deliyannis, Demarque, Dotter, Edvardsson, Freeman, Friel, Frinchaboy, Frinchaboy, Garnett, Gratton, Hirshfeld, Jacobson, Jeffrey D. Cummings, King, Korn, Kurucz, McClure, Meusinger, Michaud, Origlia, Peterson, Piatti, Pietrinferni, Pompéia, Prantzos, Ramírez, Ramírez, Richard, Rocha-Pinto, Ryan M. Maderak, Schlegel, Sills, Twarog, Twarog, Twarog, Twarog, Valenti, van Zee, VandenBerg, Wyse, Yong   +57 more
core   +1 more source