Results 71 to 80 of about 35,917 (290)

Kampo medicines, Rokumigan, Hachimijiogan, and Goshajinkigan, significantly inhibit glucagon-induced CREB activation

Heliyon, 2020
The pathophysiology of type 2 diabetes mellitus (T2DM) is characterized by not only insulin resistance, but also the abnormal regulation of glucagon secretion, suggesting that antagonizing the glucagon-induced signaling pathway has therapeutic potential ...
Megumi Funakoshi-Tago, Seisho Yu, Akira Kushida, Kazusane Takeuchi, Hiroomi Tamura   +4 more
doaj   +1 more source

Nonthermal Emissions from a Head–Tail Radio Galaxy in 3D Magnetohydrodynamic Simulations

The Astrophysical Journal, 2023
We present magnetohydrodynamic simulations of a jet–wind interaction in a galaxy cluster and the radio to gamma-ray and neutrino emissions from this “head–tail galaxy.” Our simulation follows the evolution of cosmic-ray (CR) particle spectra with energy ...
Takumi Ohmura, Katsuaki Asano, Kosuke Nishiwaki, Mami Machida, Haruka Sakemi   +4 more
doaj   +1 more source

Cosmic Shear Analysis with CFHTLS Deep data

, 2005
We present the first cosmic shear measurements obtained from the T0001 release of the Canada-France-Hawaii Telescope Legacy Survey. The data set covers three uncorrelated patches (D1, D3 and D4) of one square degree each observed in u*, g', r', i' and z'
Bacon, Bacon, Bartelmann, Benabed, Benabed, Bernardeau, Bertin, Bolzonella, Boulade, Brodwin, Bruzual, Cooray, Crittenden, Crittenden, E. Semboloni, Erben, Fahlman, Fernández-Soto, H. Hoekstra, Heymans, Heymans, Hirata, Hirata, Hoekstra, Hoekstra, Hoekstra, I. Tereno, Jain, K. Benabed, Kaiser, King, L. C. Parker, L. Fu, L. van Waerbeke, Le Fèvre, Linder, Luppino, M. J. Hudson, McCracken, Mellier, Munshi, Munshi, Peacock, Pen, Perlmutter, R. Maoli, Riess, Riess, Réfrégier, S. D. J. Gwyn, Schneider, Schneider, Schneider, Smith, Spergel, Van Waerbeke, Van Waerbeke, Van Waerbeke, Van Waerbeke, Wittman, Y. Mellier   +60 more
core   +2 more sources

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Perturbative Bottom-up Approach for Neutrino Mass Matrix in Light of Large \theta_{13} and Role of Lightest Neutrino Mass

, 2013
We discuss the role of lightest neutrino mass (m_0) in the neutrino mass matrix, defined in a flavor basis, through a bottom-up approach using the current neutrino oscillation data. We find that if m_0 < 10^{-3} eV, then the deviation \delta M_\nu in the
Ch, Upender, Dutta, Rupak, Giri, Anjan K., Sahu, Narendra   +3 more
core   +1 more source

Passivation‐Induced Species Dynamics and Microstructural Evolution in Solid‐State Lithium–Sulfur Cathodes

Advanced Science, EarlyView.
The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma, Bairav S. Vishnugopi, Elif Pınar Alsaç, Matthew T. McDowell, Partha P. Mukherjee   +4 more
wiley   +1 more source

Cosmic Microwave Background, Accelerating Universe and Inhomogeneous Cosmology [PDF]

, 2005
We consider a cosmology in which a spherically symmetric large scale inhomogeneous enhancement or a void are described by an inhomogeneous metric and Einstein's gravitational equations.
Barausse E Matarrese S Riotto A, Bondi H, Bonnor W B, Coles P, Contaldi C R, Copi C J Huterer D Starkman G D, Cruz M, Dennis M R, Dennis M R, Donoghue E P Donoghue J F, Dyer C C, Eriksen H K, Eriksen H K, Flanagan E E, Geshnizjani G Chung D J H, Giovannini M, Glück M Pisano C, Górski K M Hivon E Wandelt B, Hajian A Souradeep T, Hajian A Souradeep T Cornish N J, Hansen F K, Hansen F K Banday A J Górski K M, Hirata C M Seljak U, J W Moffat, Katz G Weeks J, Kolb E W Matarrese S Notari A Riotto A, Kolb E W Matarrese S Notari A Riotto A, Komatsu E Spergel D N Wandelt B D, Krasiński A, Land K Magueijo J, Land K Magueijo J, Land K Magueijo J, Land K Magueijo J, Land K Magueijo J, Larson D L Wandelt B D, Lemaître G, Lemaître G, Moffat J W, Mukherjee P Wang Y, Notari A, Raine D J, Rees M J, Riess A G, Räsänen S, Räsänen S, Siegel E R Fry J N, Straumann N, Tolman R C, Vielva P, Weeks J R, Wiltshire D L   +50 more
core   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Cosmic Union of Communities: a New Concept and Technologies of Creating Cosmic Humanity [PDF]

Философия и космология, 2019
The article deals with the philosophical foundations of the theory and practice of creating Cosmic Humanity. It suggests a new idea, concept and technology of organizing cosmic communities, i.e.
Sergey Krichevsky
doaj   +1 more source

Ice Age Epochs and the Sun's Path Through the Galaxy

, 2005
We present a calculation of the Sun's motion through the Milky Way Galaxy over the last 500 million years. The integration is based upon estimates of the Sun's current position and speed from measurements with Hipparcos and upon a realistic model for the
Amaral L. H., D. R. Gies, Feast M., Ibata R. A., Imbrie J., J. W. Helsel, Jenkins A., Matsumoto M., Rautiainen P.   +8 more
core   +1 more source