Results 71 to 80 of about 102,940,073 (295)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Nonthermal Emissions from a Head–Tail Radio Galaxy in 3D Magnetohydrodynamic Simulations

The Astrophysical Journal, 2023
We present magnetohydrodynamic simulations of a jet–wind interaction in a galaxy cluster and the radio to gamma-ray and neutrino emissions from this “head–tail galaxy.” Our simulation follows the evolution of cosmic-ray (CR) particle spectra with energy ...
Takumi Ohmura, Katsuaki Asano, Kosuke Nishiwaki, Mami Machida, Haruka Sakemi   +4 more
doaj   +1 more source

Sensitivity of the IceCube-Gen2 Surface Array for Cosmic-Ray Anisotropy Studies

The energy of the transition from Galactic to extra-galactic origin of cosmic rays is one of the major unresolved issues of cosmic-ray physics. However, strong constraints can be obtained from studying the anisotropy in the arrival directions of cosmic ...
Anton, G., Basu, V., Baricevic, M., Barwick, S.W., Ashida, Y., Abbasi, R., Adams, J., Alameddine, J.M., Amin, N.M., Bai, X., Ackermann, M., Ahlers, M., Axani, S.N., Audehm, J., Andeen, K., Agarwalla, S.K., Athanasiadou, S., Aguilar, J.A., Argüelles, C., et al., Balagopal, A.V., Deoskar, Kunal,, Hidvegi, Attila,, Hultqvist, Klas,, Walck, Christian,, Finley, Chad,, Hou, W., Jansson, Matti,, Zimmerman, M.   +28 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Kampo medicines, Rokumigan, Hachimijiogan, and Goshajinkigan, significantly inhibit glucagon-induced CREB activation

Heliyon, 2020
The pathophysiology of type 2 diabetes mellitus (T2DM) is characterized by not only insulin resistance, but also the abnormal regulation of glucagon secretion, suggesting that antagonizing the glucagon-induced signaling pathway has therapeutic potential ...
Megumi Funakoshi-Tago, Seisho Yu, Akira Kushida, Kazusane Takeuchi, Hiroomi Tamura   +4 more
doaj   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Search for the Gravitational-wave Background from Cosmic Strings with the Parkes Pulsar Timing Array Second Data Release

The Astrophysical Journal, 2022
We perform a direct search for an isotropic stochastic gravitational-wave background (SGWB) produced by cosmic strings in the Parkes Pulsar Timing Array (PPTA) Data Release 2 (DR2).
Zu-Cheng Chen, Yu-Mei Wu, Qing-Guo Huang
doaj   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

The 22-Year Hale Cycle in Cosmic Ray Flux – Evidence for Direct Heliospheric Modulation [PDF]

, 2014
The ability to predict times of greater galactic cosmic ray (GCR) fluxes is important for reducing the hazards caused by these particles to satellite communications, aviation, or astronauts.
Thomas, SR, Lockwood, M, Owens, MJ
core  

Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery

Advanced Science, EarlyView.
DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang   +8 more
wiley   +1 more source