Results 131 to 140 of about 205,622 (234)

Flow Cytometry: Advances, Challenges and Trends

BioEssays, Volume 48, Issue 1, January 2026.
Recent advances in flow cytometry span hardware, data processing, and AI‐driven analytics. Emerging modalitiesincluding spectral, imaging, mass, and nano/EV cytometryenable higher‐parameter and small‐particle detection. Integrated machine learning drives a shift from manual gating toward automated multi‐omics workflows.
J. Paul Robinson, Grzegorz B. Gmyrek, Bartek Rajwa   +2 more
wiley   +1 more source

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source

Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development

International Journal of Molecular Sciences
Determining a novel etiology and mechanism of human cancer requires extraction of characteristic mutational signatures derived from chemical substances.
Shinya Hasegawa, Yutaka Shoji, M. Kato, Asmaa Elzawahry, M. Nagai, Min Gi, Shugo Suzuki, Hideki Wanibuchi, S. Mimaki, K. Tsuchihara, Y. Totsuka   +10 more
semanticscholar   +1 more source

The Mutation Patterns of MET Gene in Lung Cancer and Brain Tumors: Clinical and Therapeutic Implications

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Objectives MET aberrations are capable of triggering oncogenesis through multiple clinical significance genomic alterations. In non‐small cell lung cancer, MET exon 14 skipping and MET amplification confer sensitivity to MET tyrosine kinase inhibitors. The MET gene is also one of the druggable genes in high‐grade gliomas. However, a systematic
Yu Zhang, Ningning Luo, Minghui Ge, Yanxiang Zhang, Dongsheng Chen, Yongmeng Li   +5 more
wiley   +1 more source

Plasma Fibrinogen Predicts Response to Immune Checkpoint Inhibitor by Inflammatory Tumor Microenvironment in Esophageal Cancer

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Plasma fibrinogen (FNG) is a prognostic marker in esophageal squamous cell carcinoma (ESCC). However, its predictive value for immune checkpoint inhibitor (ICI) efficacy and the underlying mechanisms remain unclear. This study aimed to evaluate the clinical significance of plasma FNG levels in ICI‐treated ESCC patients and ...
Keiso Ho, Satoru Matsuda, Eisuke Booka, Wataru Soneda, Jun Okui, Shota Hoshino, Masashi Takeuchi, Kazumasa Fukuda, Sara Horie, Yuki Saito, Yasunori Kogure, Hirofumi Kawakubo, Kensuke Hara, Hajime Okita, Keisuke Kataoka, Shigeki Sekine, Hiroya Takeuchi, Yuko Kitagawa   +17 more
wiley   +1 more source

Assessment of Circulating Tumor DNA for Early Detection of Hepatocellular Carcinoma in Alpha‐Fetoprotein–Negative Patients With Cirrhotic Nodules

JGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Aims Early detection is essential for improving hepatocellular carcinoma's (HCC) prognosis. However, the diagnostic performance of the current interventions remains unsatisfactory, particularly in patients with cirrhotic nodules. We aimed to develop a predictive model for the early detection of HCC using circulating tumor DNA (ctDNA) profiles ...
Li‐Jun Chang, Ming‐Chin Yu, Wei‐Chen Lee, Fu‐Chun Chan, Ying‐Jun Pan, Dar‐In Tai, Wen‐Hui Su   +6 more
wiley   +1 more source

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations

MedComm, Volume 7, Issue 1, January 2026.
This study utilizes whole‐genome sequencing of 197 paired samples to conduct mutational profiling of colorectal cancer (CRC) in Korean patients, identifying novel driver genes associated with recurrence. The research provides insights into oncogenic pathways and highlights clinically significant variants, emphasizing the importance of ethnic diversity ...
Junho Kang, Dong Min Lim, Young‐Joon Kim, Hyeran Shim, Tae‐You Kim, Kyu Joo Park, Sung‐Bum Kang, Chang Sik Yu, Jong Lyul Lee, Yeuni Yu, Hansong Lee, Eun Jung Kwon, Hyo Min Kim, Seongik Mun, Donghee Kwak, Hae Seul Lee, Hye Jin Heo, Eun Kyoung Kim, Seung Eun Baek, Jong‐Wook Park, Sung Uk Bae, Taeg Kyu Kwon, Dongjun Lee, Kihun Kim, Chang‐Kyu Oh, Dai Sik Ko, Sunghwan Cho, Hae Ryoun Park, Shin Kim, Yun Hak Kim   +29 more
wiley   +1 more source

Disordered N‐termini enhance the thermostability of SGNH‐hydrolase family polyesterases

Protein Science, Volume 35, Issue 1, January 2026.
Abstract Polyesters are widely used plastics that persist in the environment due to their resistance to degradation. Microbial polyesterases potentially offer recycling and remediation solutions. However, most polyesterases lack the thermostability and catalytic efficiency required for practical application.
F. Hafna Ahmed, Lygie Esquirol, Santana Royan, Mitchell M. Birgan, Nigel G. French, Sophia Newton, Alessandro T. Caputo, Colin Scott   +7 more
wiley   +1 more source

The structural heterogeneity of AKT autoinhibition

Protein Science, Volume 35, Issue 1, January 2026.
Abstract AKT is key to controlling cell growth through the PI3K/AKT/mTOR pathway. In the cytosol, in the absence of stimulus, AKT is autoinhibited to prevent uncontrolled activation. Increased AKT activity contributes to tumor growth by phosphorylating numerous downstream targets.
Liang Xu, Meryem Eren, Jackson Weako, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +6 more
wiley   +1 more source

Simulations of Radiological Dose Quantities in Astronauts During Solar Energetic Particle Events Across Modern Space History

Space Weather, Volume 24, Issue 1, January 2026.
Abstract Solar Particle Events (SPEs) represent one of the most significant hazards to future crewed space missions. Accurate assessment of radiation doses received by astronauts during these events is essential for determining the shielding requirements in spacecraft and off‐planet shelter design.
Sylvain Blunier, Piers Jiggens, Juan A. Valdivia, Aidan Cowley   +3 more
wiley   +1 more source