Results 131 to 140 of about 194,869 (207)

Does the worsening galactic cosmic radiation environment observed by CRaTER preclude future manned deep space exploration? [PDF]

, 2014
The Sun and its solar wind are currently exhibiting extremely low densities and magnetic field strengths, representing states that have never been observed during the space age.
Blake, J. B., Case, Anthony, Joyce, Colin J., Kasper, Justin, Mazur, J. E., Petro, N., Porter, Jamie A., Quinn, M., Schwadron, Nathan A., Smith, Charles W., Smith, Sonya S., Spence, Harlan E., Townsend, Lawrence W., Turner, R., Wilson, Jody K., Zeitlin, Cary   +15 more
core   +1 more source

Venetoclax Alone or in Combination With Chemotherapy in Paediatric and Adolescent/Young Adult Patients With Relapsed/Refractory Acute Myeloid Leukaemia

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Background Venetoclax is a potent, oral BCL‐2 inhibitor approved as combination therapy for the treatment of adults with newly diagnosed acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy. This study evaluated the safety and preliminary efficacy of venetoclax alone or combined with chemotherapy in paediatric and ...
Seth E. Karol, Seong L. Khaw, C. Michel Zwaan, Andre Baruchel, Henrique Bittencourt, Todd M. Cooper, Christian Flotho, Christopher Fraser, Christopher J. Forlenza, Kelly C. Goldsmith, Margaret E. Macy, Daniel A. Morgenstern, Maureen M. O'Brien, Arnaud Petit, David S. Ziegler, Dirk Reinhardt, Joseph T. Opferman, Jeffrey E. Rubnitz, Maika Onishi, Diana R. Dunshee, Fengjiao Dunbar, Deeksha Vishwamitra, Jeremy A. Ross, Xin Chen, Kristina Unnebrink, Maja Kammerlander, Ahmed Hamed Salem, Tammy L. Palenski, Gauri Sunkersett, Andrew E. Place   +29 more
wiley   +1 more source

Septin mutations in human cancers

Frontiers in Cell and Developmental Biology, 2016
Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS oncogenes. Septin expression levels are altered in many cancers and new advances point to how abnormal septin expression may contribute to the progression of ...
Elias T Spiliotis, Dimitrios Angelis
doaj   +1 more source

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. [PDF]

, 2016
Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal evolutionary processes.
Berman, Benjamin P, Cai, Yan, Chang, Chen, Dinh, Huy Q, Hao, Jia-Jie, Jiang, Yan-Yi, Jiang, Ye, Koeffler, H Phillip, Lin, De-Chen, Lu, Chen-Chen, Mayakonda, Anand, Shi, Zhi-Zhou, Wang, Jin-Wu, Wang, Ming-Rong, Wei, Wen-Qiang, Xu, Xin, Zhan, Qi-Min, Zhang, Yu   +17 more
core  

Polo‐Like Kinase 1 Expression in Colorectal Cancer: Association With RAS Mutations

Cancer Science, Volume 116, Issue 7, Page 2032-2039, July 2025.
PLK1 expression may serve as a biomarker for adjuvant chemotherapy resistance in CRC. This study focused on the relationship between PLK1 expression and RAS mutation, which has been reported to be highly sensitive to PLK1 inhibitors. RAS mutation with high PLK1 expression predicts poorer survival in adjuvant‐treated CRC patients.
Yasushi Tanaka, Eiji Oki, Ryota Nakanishi, Tetsuro Kawazoe, Kensuke Kudo, Yoko Zaitsu, Yuichi Hisamatsu, Koji Ando, Yoshinao Oda, Tomoharu Yoshizumi   +9 more
wiley   +1 more source

Relationship of fat in the pancreas with cardiovascular disease: A systematic review and meta‐analysis

Obesity Reviews, Volume 26, Issue 7, July 2025.
Summary Background General adiposity is a well‐known risk factor for cardiovascular disease. By contrast, the interconnection between high intra‐pancreatic fat deposition and cardiovascular disease has been scantily investigated. This field‐wide systematic review aimed to map the available evidence on cardiovascular disease according to the fat content
Yingxin Zhang, Yutong Liu, Maxim S. Petrov   +2 more
wiley   +1 more source

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Profiling PIK3CA variants in disorders of somatic mosaicism

Genetics in Medicine Open, 2023
Purpose: Variants in PIK3CA (encoding p110α; the catalytic subunit of PI3K) characterize some disorders of somatic mosaicism (DoSM) conditions with clinical features, including sporadic overgrowth and vascular malformations.
Bahareh A. Mojarad, Patricia V. Hernandez, Michael J. Evenson, Meagan M. Corliss, Sarah L. Stein, Amy Theos, Carrie C. Coughlin, Bryan Sisk, Maithilee Menezes, Molly C. Schroeder, Jonathan W. Heusel, Julie A. Neidich, Yang Cao   +12 more
doaj  

Comprehensive genomic characterization defines human glioblastoma genes and core pathways. [PDF]

, 2008
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation.
Cancer Genome Atlas Research Network
core   +1 more source

Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.

PLoS ONE
The cancer hazard associated with lifetime exposure to radiofrequency radiation (RFR) was examined in Sprague Dawley (SD) rats at the Ramazzini Institute (RI), Italy. There were increased incidences of gliomas and cardiac schwannomas.
Ashley M Brooks, Andrea Vornoli, Ramesh C Kovi, Thai Vu T Ton, Miaofei Xu, Ahmed Mashal, Eva Tibaldi, Federica Gnudi, Jian-Liang Li, Robert C Sills, John R Bucher, Daniele Mandrioli, Fiorella Belpoggi, Arun R Pandiri   +13 more
doaj   +1 more source