Biological implications of high-energy cosmic ray induced muon flux in the extragalactic shock model
, 2011 A ~ 62 My periodicity in fossil biodiversity has been observed in independent studies of paleontology databases over ~0.5Gy. The period and phase of this biodiversity cycle coincides with the oscillation of our solar system normal to the galactic disk ...
Adrian L. Melott +29 more
core +1 more source
Effect of bet missense mutations on bromodomain function, inhibitor binding and stability [PDF]
, 2016 Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a ...
Alessandra, Pasquo +7 more
core +2 more sources
Modelling the order of driver mutations and metabolic mutations as structures in cancer dynamics [PDF]
arXiv, 2017 Recent works have stressed the important role that random mutations have in the development of cancer phenotype. We challenge this current view by means of bioinformatic data analysis and computational modelling approaches. Not all the mutations are equally important for the development of metastasis.
arxiv
Predicting the functional impact of protein mutations: application to cancer genomics
Nucleic Acids Research, 2011 As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal.
B. Reva, Yevgeniy Antipin, C. Sander
semanticscholar +1 more source
Evaluating a healthcare data warehouse for cancer diseases [PDF]
arXiv, 2013 This paper presents the evaluation of the architecture of healthcare data warehouse specific to cancer diseases. This data warehouse containing relevant cancer medical information and patient data. The data warehouse provides the source for all current and historical health data to help executive manager and doctors to improve the decision making ...
arxiv
Germline genetic variants were interactively associated with somatic alterations in gastric cancer
Cancer Medicine, 2018 Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang +4 more
doaj +1 more source
Improved survival of cancer patients admitted to the ICU between 2002 and 2011 at a U.S. teaching hospital [PDF]
arXiv, 2018 Over the past decades, both critical care and cancer care have improved substantially. Due to increased cancer-specific survival, we hypothesized that both the number of cancer patients admitted to the ICU and overall survival have increased since the millennium change.
arxiv
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and although many patients respond to induction therapy, those who relapse or have refractory disease face a poor prognosis. Venetoclax has promising preclinical and clinical activity in ALL.
Andrew E. Place +21 more
wiley +1 more source
Impact of Minimal Residual Disease on Early Recurrence of Liver Metastatic Colorectal Cancer
Cancer Science, EarlyView.Our study highlights the significant role of minimal residual desease(MRD) assessment in patients with reseble CRLM, particularly in predicting early recurrence and guiding treatement decisions, suggesting that adjuvant chemotherapy may not offer substantial benefits for MRD‐negative patients.
Mampei Kawashima +10 more
wiley +1 more source
Novel Mining of Cancer via Mutation in Tumor Protein P53 using Quick Propagation Network [PDF]
International Journal of Computer Science and Electronics
Engineering IJCSEE, Volume 3, Issue 2, 2015, 2015 There is multiple databases contain datasets of TP53 gene and its tumor protein P53 which believed to be involved in over 50% of human cancers cases, these databases are rich as datasets covered all mutations caused diseases (cancers), but they haven't efficient mining method can classify and diagnosis mutations patient's then predict the cancer of ...
arxiv