Results 111 to 120 of about 16,100 (233)

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, Volume 13, Issue 34, 19 June 2026.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, Volume 13, Issue 32, 9 June 2026.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Supplementary Tables 1-4 from Clinical Outcomes in Non–Small Cell Lung Cancers Harboring Different Exon 19 Deletions in EGFR

, 2012
PDF file - 122K, Catalogue of Somatic Mutations in Cancer (COSMIC) Database for ...
Kuei-Pin Chung (8362761), Jin-Yuan Shih (59760), Jenn-Yu Wu (4238335), Chong-Jen Yu (58765), James Chih-Hsin Yang (7428557), Shang-Gin Wu (210423), Pin-Fei Wei (14984595), Pan-Chyr Yang (19231)   +7 more
core   +1 more source

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs

Nucleic Acids Res., 2017
Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, we updated the lncRNASNP to version 2 (http ...
Ya-Ru Miao, Wei Liu, Qiong Zhang, An-Yuan Guo   +3 more
semanticscholar   +1 more source

Unveiling Candidate Markers for Drug Resistance or Synthetic Lethality in Cervical Cancer: Integrative Analysis of Genetic and Pharmacoprofiling

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Suzy Scholl, Elaine Del Nery, Pierre Gestraud, Maral Halladjian, Elodie Girard, Adèle Soria, Elodie Anthony, Leanne De Koning, Nicolas Servant, Els Berns, Maud Kamal   +10 more
wiley   +1 more source

Identification of Cancer-Associated Proteins in Colorectal Cancer Using Mass Spectrometry

Proteomes
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with a multifactorial etiology involving genetic and environmental factors. Advanced proteomics offers valuable insights into the molecular mechanisms of cancer,
Naoyuki Toyota, Ryo Konno, Shuhei Iwata, Shin Fujita, Yoshio Kodera, Rei Noguchi, Tadashi Kondo, Yusuke Kawashima, Yuki Yoshimatsu   +8 more
doaj   +1 more source

Statistical method on nonrandom clustering with application to somatic mutations in cancer

BMC Bioinformatics, 2010
Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A, Lunney Elizabeth A, Pavlicek Adam, Ye Jingjing, Teng Chi-Hse   +4 more
doaj   +1 more source

Inhibition of IL-1β by canakinumab may be effective against diverse molecular subtypes of lung cancer: An exploratory analysis of the CANTOS trial

, 2020
In the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), inhibition of the IL1β inflammatory pathway by canakinumab has been shown to significantly reduce lung cancer incidence and mortality.
Silvestro, Angela, Wang, Xiaoshan, Prescott, Margaret, Svensson, Eric, Baum, Jason, Wong, Connie, Beste, Michael, Krajkovich, Lynne, Dugan, Margaret, Martin, Ann Marie, Ridker, Paul, Bharani Dharan, Bharani, Wang, Amanda, Xu, Siyan   +13 more
core  

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure

Genes and Environment
Background Sinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the non-intestinal-type sinonasal adenocarcinoma (non-ITAC). Occurrence of ITAC is strongly associated with
Lauri J. Sipilä, Riku Katainen, Mervi Aavikko, Janne Ravantti, Iikki Donner, Rainer Lehtonen, Ilmo Leivo, Henrik Wolff, Reetta Holmila, Kirsti Husgafvel-Pursiainen, Lauri A. Aaltonen   +10 more
doaj   +1 more source