Results 131 to 140 of about 16,100 (233)

Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development

International Journal of Molecular Sciences
Determining a novel etiology and mechanism of human cancer requires extraction of characteristic mutational signatures derived from chemical substances.
Shinya Hasegawa, Y. Shoji, M. Kato, Asmaa Elzawahry, M. Nagai, Min Gi, Shugo Suzuki, Hideki Wanibuchi, S. Mimaki, K. Tsuchihara, Y. Totsuka   +10 more
semanticscholar   +1 more source

Prognostic Value and Therapeutic Response Prediction of BRAF, RAS, and TERT Gene Mutations in Thyroid Cancer: A Large-Scale Analysis Based on the Cosmic Database

Abstract Objective : To systematically evaluate the distribution characteristics of key gene mutations (BRAF, RAS [HRAS, KRAS, NRAS], TERT) in thyroid cancer, explore their correlations with clinicopathological features, prognosis, and therapeutic response, and construct a polygenic prognostic ...
openaire   +1 more source

Tumour‐Derived Extracellular Vesicles Reprogramme Tumour‐Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Clear cell renal cell carcinoma (ccRCC)‐derived extracellular vesicles (EVs) play a pivotal role in myeloid cell differentiation toward immunosuppressive phenotypes, yet the underlying mechanisms remain poorly understood. Through integrated single‐nucleus RNA sequencing, EV proteomics, and phenotype validation, we identified NOD1, a pattern ...
Xiu‐wu Pan, Mu‐chen Li, Tian‐yue Yang, Yi‐fan Liu, Jia‐lin Zhou, Yi‐fan Tang, Hong‐feng Zheng, Jian‐gui Liu, Zi‐chang Liu, Wen‐jie Ma, Wen‐yan Li, Zi‐xuan Gong, Shun Zhang, Hang‐biao Zhang, Bing‐nan Lu, Yun‐tao Yao, Dong‐hao Lyu, Guan‐yu Zhu, Yuan‐bo Zong, Han‐lin Yao, Ai‐ping Zhang, Jin Zeng, Si‐tu Xiong, Ke‐qin Dong, Wang Zhou, Bin Fu, Xin‐gang Cui   +26 more
wiley   +1 more source

Additional file 8: of Exome scale map of genetic alterations promoting metastasis in colorectal cancer

, 2018
Table S7. EMV Cancer driver mutations according to CHASM algorithm. Chrom – chromosome number, Position – mutation position, Ref – reference base, Alt – variant base, Sample.ID – sample with mutation, HUGO.symbol – HUGO gene symbol, Protein.sequence ...
Andrzej Mroz (5771921), Jerzy Ostrowski (170111), Krzysztof Goryca (240597), Michalina Dabrowska (800221), Magdalena Skrzypczak (240596), Krzysztof Ginalski (8940), Marta Grzelak (5771918), Maria Kulecka (2503180), Andrzej Rutkowski (170103), Michal Mikula (240599), Agnieszka Paziewska (170076), Katarzyna Paczkowska (5771924)   +11 more
core   +1 more source

On the Role of Electron Precipitation in Excess Radiation Doses Measured at Aviation Altitudes

Space Weather, Volume 24, Issue 6, June 2026.
Abstract Radiation from space in the form of galactic cosmic rays (GCRs) generates a persistent background of ionizing radiation in Earth's atmosphere. The dose rate of ionizing radiation due to GCRs increases from sea level to aviation altitudes.
Julia Luna Claxton, Robert Marshall
wiley   +1 more source

Residues Lys-6 to Arg-14 of PTEN and the canonical PIP₂-binding motif.

, 2015
Each conserved residue in this motif is altered in cancer according to the COSMIC database.
Sean B. Johnston (685153), Ronald T. Raines (369613)   +1 more
core   +1 more source

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Cryo‐EM structure of ALC1 in an open conformation bound to a PARylated nucleosome

Acta Crystallographica Section D, Volume 82, Issue 6, Page 683-699, June 2026.
Reanalysis of a publicly available cryo‐EM dataset identifies a new conformation of the oncogenic chromatin remodeler ALC1/CHD1L bound to a PARylated nucleosome. This new structure reveals the position of the macro domain in the complex, and may help to understand the large conformational change leading to the activation of ALC1.Nucleosomes are the ...
Hannah R. Bridges, Luka Bacic, Sebastian Deindl, Guillaume Gaullier   +3 more
wiley   +1 more source

Data curation-research: Practices of data standardization and exploration in a precision medicine database

, 2020
Key to precision medicine is the development of expert database projects that gather data, integrate them in the pre-existing database, and publish the product of their processing for others to make use of.
N Tempini (21848336)
core  

Generating a focused view of disease ontology cancer terms for pan-cancer data integration and analysis.

, 2015
Bio-ontologies provide terminologies for the scientific community to describe biomedical entities in a standardized manner. There are multiple initiatives that are developing biomedical terminologies for the purpose of providing better annotation, data ...
Hu, Ying, + 10 more, Colbert, Maureen, Wu, Tsung-Jung, Mazumder, Raja, Chen, Qing-Rong, Schriml, Lynn M., Crichton, Daniel J.   +7 more
core   +1 more source