Results 101 to 110 of about 16,100 (233)

Identifying pathways affected by cancer mutations

, 2018
Mutations in 15 cancers, sourced from the COSMIC Whole Genomes database, and 297 human pathways, arranged into pathway groups based on the processes they orchestrate, and sourced from the KEGG pathway database, have together been used to identify ...
Iengar, Prathima, Prathima Iengar
core   +1 more source

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Abstract PR08: SynMICdb: The database for synonymous mutations in cancer identifies recurrent changes in conserved loci paralleling missense mutations

, 2017
Genome sequencing studies reveal an overwhelming number of mutations in cancer. Chromosomal losses and gains or missense and nonsense point mutations altering tumor suppressor genes and oncogenes are widely studied.
Yogita Sharma, Karine Boulay, Sven Diederichs   +2 more
core   +1 more source

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer

Frontiers in Oncology
IntroductionClinical workflows to analyze variants of unknown significance (VUSs) found in clinical next generation sequencing (NGS) are labor intensive, requiring manual analysis of published data for each variant.
Amith Rangarajan, Ilona Sviezhentseva, Emma Gunderson, Yana Pikman, Yana Pikman, Matthew P. Jacobson, Beth Apsel Winger, Beth Apsel Winger   +7 more
doaj   +1 more source

Combo Deals, Junk Meals: A Systematic Review Examining the Healthiness of Foods Promoted on Meal Delivery Apps

Obesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT Introduction Meal delivery apps increase access to unhealthy foods, contributing to an obesogenic environment. Promotions are widely used on these apps to influence consumer choice. This systematic review aimed to synthesize evidence on the healthiness of foods promoted on meal delivery apps.
Jessica Morrison, Joanne Dono, Simone Pettigrew, Caroline Miller   +3 more
wiley   +1 more source

Disease-associated missense mutations in human LACTB.

, 2022
Mutations associated with various cancers were compiled from the Catalogue of Somatic Mutations in Cancer (COSMIC), the Genome Aggregation Database (gnomAD), and The Cancer Genome Atlas Program (TCGA). (PDF)
Halil Aydin (14279451), Jeremy A. Bennett (14279442), Adam P. Voss (14279448), Lottie R. Steward (14279445), Johannes Rudolph (1340352)   +4 more
core   +1 more source

Predicting the functional impact of protein mutations: application to cancer genomics

Nucleic Acids Research, 2011
As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal.
B. Reva, Y. Antipin, C. Sander
semanticscholar   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

Cancer Medicine, 2018
Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang, Yuzhuo Wang, Tian Tian, Gangqiao Zhou, Guangfu Jin   +4 more
doaj   +1 more source