Results 101 to 110 of about 7,424,997 (207)

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer

Frontiers in Oncology
IntroductionClinical workflows to analyze variants of unknown significance (VUSs) found in clinical next generation sequencing (NGS) are labor intensive, requiring manual analysis of published data for each variant.
Amith Rangarajan, Ilona Sviezhentseva, Emma Gunderson, Yana Pikman, Yana Pikman, Matthew P. Jacobson, Beth Apsel Winger, Beth Apsel Winger   +7 more
doaj   +1 more source

A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide. Genetic mutations in genes involved in key cellular functions such as BRCA1/2 play a central role in tumorigenesis and have major implications for targeted therapeutic strategies, especially the use of poly (ADP‐ribose) polymerase (PARP ...
Nihel Ammous‐Boukhris, Rania Abdelmaksoud‐Dammak, Ameni Feki, Souhir Khemiri, Slim Charfi, Tahia Sallemi‐Boudawara, Jamel Daoud, Afef Khanfir, Raja Mokdad Gargouri   +8 more
wiley   +1 more source

Cancer Trends: Cancer of the pancreas

, 2012
Cancer of the pancreas accounts for approximately 2.5% of all invasive cancers and is the 9th most commonly diagnosed cancer in Ireland.1 Almost 400 cases of pancreatic cancer were diagnosed annually between 1994 and 2010 (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Germline genetic variants were interactively associated with somatic alterations in gastric cancer

Cancer Medicine, 2018
Genome‐wide association studies have identified several germline variants in gastric cancer. Meanwhile, sequencing studies have characterized extensive somatic alterations that arise during gastric carcinogenesis.
Xu Zhang, Yuzhuo Wang, Tian Tian, Gangqiao Zhou, Guangfu Jin   +4 more
doaj   +1 more source

DNA Replication Stress‐Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center‐Derived B‐Lymphomagenesis

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).
Santosh Kumar Gothwal, Kyoko Oichai, Hongtae Kim, Kyungjae Myung, Jacqueline H. Barlow   +4 more
wiley   +1 more source

Decoding the Heterogeneity of Diffuse Large B‐Cell Lymphomas: A Comprehensive Genetic, Transcriptomic, and Phenotypic Profiling of B‐Cell Lymphoma Cell Lines

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most prevalent form of non‐Hodgkin lymphoma, exhibiting significant molecular and clinical heterogeneity. Advances in classification integrating phenotypic, genetic, and transcriptomic features have improved diagnosis and prognosis.
Marina Pérez‐Aguilera, Lucía Pedrosa, Sagrario Gómez, Sara Salazar‐Ortego, Ismael Fernández‐Miranda, Rafael Muñoz‐Viana, Paloma Martín‐Acosta, Beatriz L. Martín‐Lunas, Rebeca Jimeno, Natalia Yanguas‐Casás, Beatriz Horcajo, Giovana Roncador, José A. Martínez‐Climent, Ana Ortega‐Molina, Margarita Sánchez‐Beato   +14 more
wiley   +1 more source

Circulating Tumor DNA and Immune Response Markers for Improved Treatment Outcome Prediction in Diffuse Large B‐Cell Lymphoma: A Scoping Review

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Early identification of refractory disease remains a significant unmet clinical need in patients with diffuse large B‐cell lymphoma (DLBCL). This scoping review was conducted to assess the current knowledge on the use of circulating tumor DNA (ctDNA), either alone or in combination with immune markers, as predictive tools for treatment outcome
Ailin McMahon, Elizabeth J. Ryan, Sarah Dillon, Ruth Clifford   +3 more
wiley   +1 more source

Cancer Trends: Cancers of the testis

, 2012
An average of 132 cases of testicular cancer was diagnosed per year in Ireland between 1994 and 2010 (Table 1). Almost all cases were microscopically verified (98%) and were germ-cell tumours—57% of which were seminomatous and 40% non-seminomatous ...
National Cancer Registry Ireland (NCRI)
core  

Somatic cancer mutations of LGR6 listed in the COSMIC database as of Jan-2012.

, 2013
Somatic cancer mutations of LGR6 listed in the COSMIC database as of Jan-2012.
Qingyun Liu (322730), Jing Yi (81891), Xing Gong (322727), Kendra S. Carmon (322728), Qiushi Lin (322729), Anthony Thomas (149723)   +5 more
core   +1 more source

Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

Molecules
The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source