Results 81 to 90 of about 16,100 (233)
Clinical Pharmacology &Therapeutics, EarlyView.Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
wiley +1 more source
, 2018 YAP mutation in human breast cancer. TCGA and COSMIC database performed to analyse the mutations of YAP are shown in Additional file 3: Figure S1. The pie chart showing the information of mutations was generated using COSMIC databse.
Sumayya Real (5479889) +6 more
core +1 more source
Bioinform., 2019 MOTIVATION The consensus pattern of Nuclear Export Signal (NES) is a short sequence motif that is commonly identified in protein sequences, whether the motif acts as an NES (true positive) or not (false positive).
Yoonji Lee +4 more
semanticscholar +1 more source
International Journal of Cancer, EarlyView.What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago +3 more
wiley +1 more source
International Journal of Cancer, EarlyView.Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens +14 more
wiley +1 more source
, 2013 PDF file - 38K, KRAS, BRAF, PIK3CA, and PTEN status of utilized CRC cell lines.The mutation data was obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site, http://www.sanger.ac.uk/cosmic.
Farshid Dayyani (107198) +17 more
core +1 more source
, 2020 Additional file 2: Figure S1. Mutations and expression levels of CIC in CRC patient samples. a Schematic illustration of the location of point mutations in CIC identified from patients with colorectal cancer.
Dongjun Jeong (8411313) +8 more
core +1 more source
VarDB2.0 - a proteogenomics database
, 2022 This VarDB2.0 database contains variant peptide sequences from COSMIC mutation, non-synonymous SNPs, three frame translated lncRNA and Pseudogenes.The database is used in the following paper, please cite the paper if it contributes your work:Rong Xiang ...
Zhu, Y (via Mendeley Data)
core +1 more source
Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines
Genome Medicine, 2017 Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as ...
Javier A. Alfaro +5 more
doaj +1 more source
Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma
Analytical Cellular Pathology, 2023 Background. PTGES3 is upregulated in multiple cancer types and promotes tumorigenesis and progression. However, the clinical outcome and immune regulation of PTGES3 in lung adenocarcinoma (LUAD) are not fully understood.
Wenyan Jiang +5 more
doaj +1 more source