Results 71 to 80 of about 16,100 (233)

Identification of differential DNA methylation alterations of ovarian cancer in peripheral whole blood based on within-sample relative methylation orderings

Epigenetics, 2022
Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed to detect cellular DNA methylation changes in ovarian cancer (OVC) blood samples avoiding the above ...
Hongdong Li, Fengle Jiang, Yuhui Du, Na Li, Zhihong Chen, Hao Cai, You Guo, Guini Hong   +7 more
doaj   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Somatic Variations in Cervical Cancers in Indian Patients.

PLoS ONE, 2016
There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das, Akanksha Bansal, Sudha Narayan Rao, Kedar Deodhar, Umesh Mahantshetty, Shyam K Shrivastava, Karthikeyan Sivaraman, Rita Mulherkar   +7 more
doaj   +1 more source

Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder

Signal Transduction and Targeted Therapy, 2021
Neuroendocrine carcinoma (NEC) of the gallbladder (GB-NEC) is a rare but extremely malignant subtype of gallbladder cancer (GBC). The genetic and molecular signatures of GB-NEC are poorly understood; thus, molecular targeting is currently unavailable. In
Fatao Liu, Yongsheng Li, Dongjian Ying, Shimei Qiu, Yong He, Maolan Li, Yun Liu, Yijian Zhang, Qin Zhu, Yunping Hu, Liguo Liu, Guoqiang Li, Weihua Pan, Wei Jin, Jiasheng Mu, Yang Cao, Yingbin Liu   +16 more
doaj   +1 more source

Clinically Relevant Bleeding in Individuals With Cancer: Insights From a Nationwide Cohort Study

American Journal of Hematology, EarlyView.
ABSTRACT Cancer care is often complicated by coagulopathy leading to thrombosis and bleeding. While venous thromboembolism (VTE) has been extensively studied, bleeding remains an underestimated threat. To address this knowledge gap, we leveraged the Epic Cosmos database to determine the impact of cancer‐associated clinically relevant bleeding (CRB) in ...
Ming Y. Lim, Radhika Gangaraju, Omid Jafari, Zihan Yang, Joyce W. T. Tiong, Elizabeth C. L. Chiang, Shengling Ma, Jun Y. Jiang, Justine Ryu, Barbara D. Lam, Mrinal Ranjan, Ang Li   +11 more
wiley   +1 more source

CanVar: A resource for sharing germline variation in cancer patients.

, 2016
The advent of high-throughput sequencing has accelerated our ability to discover genes predisposing to disease and is transforming clinical genomic sequencing.
Chubb, D, Dobbins, SE, Houlston, RS, Broderick, P   +3 more
core   +1 more source

Somatic Evolution Introduces Distinctive Changes in Proteome Composition in Cancer Types [PDF]

, 2018
On the proteome level, somatic evolution in cancer is asymmetric, with several amino acids being irreversibly lost and the others gained across cancer types.
Цубер, Вікторія Юріївна, Tsuber, V. Yu., Цубер, Виктория Юрьевна   +2 more
core   +1 more source

The Mutational signature comprehensive analysis toolkit (musicatk) for the discovery, prediction, and exploration of mutational signatures [PDF]

, 2021
Mutational signatures are patterns of somatic alterations in the genome caused by carcinogenic exposures or aberrant cellular processes. To provide a comprehensive workflow for preprocessing, analysis, and visualization of mutational signatures, we ...
Huggins, Jonathan H, Tong, Tong, Sahelijo, Nathan, Khurshid, Zainab, Yajima, Masanao, Campbell, Joshua David, Yang, Shiyi, Chevalier, Aaron, Huggins, Jonathan H., Campbell, Joshua D.   +9 more
core   +1 more source

Structural analysis of genomic and proteomic signatures reveal dynamic expression of intrinsically disordered regions in breast cancer

bioRxiv, 2023
Structural features of proteins capture underlying information about protein evolution and function, which enhances the analysis of proteomic and transcriptomic data.
Nicole Zatorski, Yifei Sun, Abdulkadir Elmas, Christian Dallago, Tim Karl, David Stein, Burkhard Rost, Kuan-lin Huang, Martin Walsh, A. Schlessinger   +9 more
semanticscholar   +1 more source

Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling. [PDF]

PLoS ONE, 2013
Cutaneous malignant melanoma is the most fatal skin cancer and although improved comprehension of its pathogenic pathways allowed to realize some effective molecular targeted therapies, novel targets and drugs are still needed.
Ingrid Cifola, Alessandro Pietrelli, Clarissa Consolandi, Marco Severgnini, Eleonora Mangano, Vincenzo Russo, Gianluca De Bellis, Cristina Battaglia   +7 more
doaj   +1 more source