Results 51 to 60 of about 16,100 (233)

Top cancer-associated protein targets for each cell line.

, 2021
We ranked potential targets by predicted change in network potential when each protein was modeled as repressed, limited to proteins causally associated in cancer according to the Cosmic database.
Drew Williamson (11576909), Jessica Scarborough (11576912), Andrew Dhawan (561250), Jacob G. Scott (8692374), Stephen L. Lessnick (9302544), Davis T. Weaver (7411445), Kathleen I. Pishas (1991602)   +6 more
core   +1 more source

Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases

Scientific Reports
The JAK-STAT pathway is central to cytokine signaling and controls normal physiology and disease. Aberrant activation via mutations that change amino acids in proteins of the pathway can result in diseases.
Markus Hoffmann, Lothar Hennighausen
doaj   +1 more source

New Lung Cancer Panel for High-Throughput Targeted Resequencing [PDF]

Genomics & Informatics, 2014
We present a new next-generation sequencing-based method to identify somatic mutations of lung cancer. It is a comprehensive mutation profiling protocol to detect somatic mutations in 30 genes found frequently in lung adenocarcinoma.
Eun-Hye Kim, Sunghoon Lee, Jongsun Park, Kyusang Lee, Jong Bhak, Byung Chul Kim   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comprehensive Analysis of MEN1 Mutations and Their Role in Cancer

, 2020
MENIN is a scaffold protein encoded by the MEN1 gene that functions in multiple biological processes, including cell proliferation, migration, gene expression, and DNA damage repair.
Ruben C. Petreaca, Devi D. Nelakurti, Amrit L. Pappula, Swetha Rajasekaran, Wayne O. Miles   +4 more
core   +1 more source

Demographics and Clinicopathologic Profile of Pulmonary Sarcomatoid Carcinoma with Survival Analysis and Genomic Landscape

, 2023
Background: Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small cell lung cancer (NSCLC) with an aggressive clinical nature and poor prognosis.
Hina Khan, Yasinzai, Abdul Qahar Khan, Karki, Nabin R., Gul Andam, Karim, Nagla Abdel, Ahmed, Asim, Asif, Bina, Saleh Heneidi, Jaffar Khan, Khan, Israr, Khan, Imran, Heneidi, Saleh, Jaydira Del Rivero, Andam, Gul, Asim Ahmed, Khan, Jaffar, Del Rivero, Jaydira, Bina Asif, Tareen, Bisma, Kue Tylor Lee, Nabin R. Karki, Asad Ullah, Israr Khan, Nagla Abdel Karim, Kaleemullah Kakar, Abdul Qahar Khan Yasinzai, Khan, Hina, Imran Khan, Bisma Tareen, Ullah, Asad, Lee, Kue Tylor, Kakar, Kaleemullah   +31 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

RETRACTED: Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)

International Journal of Molecular Sciences, 2023
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the ...
Cathy E Richards, Yasir Y. Elamin, A. Carr, K. Gately, S. Rafee, M. Cremona, E. Hanrahan, Robert Smyth, Daniel J Ryan, R. Morgan, Susan A. Kennedy, L. Hudson, J. Fay, K. O'Byrne, B. Hennessy, S. Toomey   +15 more
semanticscholar   +1 more source

AlphaMissense Predictions and ClinVar Annotations: A Deep Learning Approach to Uveal Melanoma

Ophthalmology Science
Objective: Uveal melanoma (UM) poses significant diagnostic and prognostic challenges due to its variable genetic landscape. We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM.
David J. Taylor Gonzalez, MD, Mak B. Djulbegovic, MD, MSc, Meghan Sharma, MD, MPH, Michael Antonietti, BS, Colin K. Kim, BS, Vladimir N. Uversky, PhD, DSc, Carol L. Karp, MD, Carol L. Shields, MD, Matthew W. Wilson, MD   +8 more
doaj   +1 more source