Results 51 to 60 of about 7,424,997 (207)

Measurement of Ultra-High Energy Cosmic Rays with CHICOS [PDF]

, 2009
The California HIgh school Cosmic ray ObServatory (CHICOS) is a ground-based scintillator array designed to measure the extended air showers of ultra-high energy cosmic rays. The goal of the project is to gain insight into the origin of ultra-high energy
Brobeck, Elina
core   +1 more source

COSMIC-PopSynth/COSMIC: COSMIC v3.4.8

, 2023
What's Changed Nan check by @katiebreivik in https://github.com/COSMIC-PopSynth/COSMIC/pull/576 Remove zsun wind and add NaN catch by @katiebreivik in https://github.com/COSMIC-PopSynth/COSMIC/pull/578 Full Changelog: https://github.com/COSMIC-PopSynth/
Jeff Andrews, 1nhtran, elenagonzalez870, Katie Breivik, Chase Kimball, Poojan, Michael Zevin, Tom Wagg, mcdigman, Carl Rodriguez, Scott Coughlin, Chirag Chawla   +11 more
core   +1 more source

AlphaMissense Predictions and ClinVar Annotations: A Deep Learning Approach to Uveal Melanoma

Ophthalmology Science
Objective: Uveal melanoma (UM) poses significant diagnostic and prognostic challenges due to its variable genetic landscape. We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM.
David J. Taylor Gonzalez, MD, Mak B. Djulbegovic, MD, MSc, Meghan Sharma, MD, MPH, Michael Antonietti, BS, Colin K. Kim, BS, Vladimir N. Uversky, PhD, DSc, Carol L. Karp, MD, Carol L. Shields, MD, Matthew W. Wilson, MD   +8 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

NMDB@Athens

, 2023
This volume documents the papers presented at the hybrid symposium on cosmic ray studies with neutron monitors in Athens in September 2022. The contributions are dedicated to six topics: cosmic rays in the heliosphere, GLE analysis and space weather ...

core   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

ANIA:ANnotation and Integrated Analysis of the 14-3-3 interactome [PDF]

, 2014
The dimeric 14-3-3 proteins dock onto pairs of phosphorylated Ser and Thr residues on hundreds of proteins, and thereby regulate many events in mammalian cells.
Murugesan, Gavuthami, Mackintosh, Carol; id_orcid, Hoxhaj, Gerta, Toth, Rachel, Tinti, Michele, Madeira, Fabio   +5 more
core   +1 more source

Clinical predictors of survival in malignant peripheral nerve sheath tumors of the head and neck: A cox regression and nomogram study

Brazilian Journal of Otorhinolaryngology
Objectives: Malignant Peripheral Nerve Sheath Tumors (MPNST) are rapidly progressing Schwann cell neoplasms. This study aimed to develop a practical clinical nomogram that predicts prognosis in patients with Head and Neck MPNST (HN-MPNST) using the ...
Sun LiNa, Tu Jianfei, Tian Zhifeng, Wang Xinbin, Wu Hui   +4 more
doaj   +1 more source

Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation

Journal of Translational Medicine, 2022
Kidney transplantation is a lifesaving option for patients with end-stage kidney disease. In Taiwan, urothelial carcinoma (UC) is the most common de novo cancer after kidney transplantation (KT). UC has a greater degree of molecular heterogeneity than do
Lee-Moay Lim, Wen-Yu Chung, Daw-Yang Hwang, Chih-Chuan Yu, Hung-Lung Ke, Peir-In Liang, Ting-Wei Lin, Siao Muk Cheng, A-Mei Huang, Hung-Tien Kuo   +9 more
doaj   +1 more source