Results 31 to 40 of about 16,100 (233)

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients

BMC Cancer, 2019
Background Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity ...
Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida   +2 more
doaj   +1 more source

Prominent features of the amino acid mutation landscape in cancer. [PDF]

PLoS ONE, 2017
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of these distinctions have been used to classify cancer subtypes and to reveal common features. Here,
Zachary A Szpiech, Nicolas B Strauli, Katharine A White, Diego Garrido Ruiz, Matthew P Jacobson, Diane L Barber, Ryan D Hernandez   +6 more
doaj   +1 more source

CALR-ETdb, the database of calreticulin variants diversity in essential thrombocythemia

Platelets, 2022
Essential thrombocythemia (ET) is a blood cancer defined by a strong increase of platelet numbers. A quarter of patients suffering from ET show mutations in the last exon of calreticulin (CALR) gene.
Nora El Jahrani, Gabriel Cretin, Alexandre G. de Brevern   +2 more
doaj   +1 more source

VarStack2-an interactive web tool for somatic variant interpretation in cancer. [PDF]

Database (Oxford)
The rapid progress in tumour genome sequencing has created a need for bioinformatics tools to interpret the clinical significance of detected variants. VarStack² integrates information from several publicly available resources, including the Catalogue of
Sreekumar N, Ahn BJ, Tian S, Uzun A, Gamsiz Uzun ED.   +4 more
europepmc   +2 more sources

Comparative study of the evolution of cancer gene duplications across fish

Evolutionary Applications, 2022
Comparative studies of cancer‐related genes not only provide novel information about their evolution and function but also an understanding of cancer as a driving force in biological systems and species’ life histories. So far, these studies have focused
Ciara Baines, Richard Meitern, Randel Kreitsberg, Tuul Sepp   +3 more
doaj   +1 more source

Ionizing and non-ionizing radiation and the risk of childhood cancer-illustrated with domestic radon and radio frequency electromagnetic field exposure [PDF]

, 2013
Background Children are exposed to many different environmental factors, including exposure to low-dose ionizing radiation and to non-ionizing radiation.
Hauri, Dimitri
core   +1 more source

CancerEnD: A database of cancer associated enhancers.

Genomics, 2020
CancerEnD is an integrated resource developed for annotating 8524 unique expressed enhancers, associated genes, somatic mutations and copy number variations of 8063 cancer samples from 18 cancer types of TCGA.
R. Kumar, Anjali Lathwal, Vinod Kumar, Sumeet Patiyal, P. Raghav, G. Raghava   +5 more
semanticscholar   +1 more source

COSMIC: somatic cancer genetics at high-resolution

Nucleic Acids Res., 2016
COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer.
S. Forbes, D. Beare, Harry Boutselakis, S. Bamford, Nidhi Bindal, J. Tate, C. Cole, Sari Ward, E. Dawson, Laura Ponting, Raymund Stefancsik, Bhavana Harsha, C. Kok, Mingming Jia, Harry C Jubb, Zbyslaw Sondka, Sam L. Thompson, Tisham De, P. Campbell   +18 more
semanticscholar   +1 more source

Identification of candidate genes for lung cancer somatic mutation test kits

Genetics and Molecular Biology, 2013
Over the past three decades, mortality from lung cancer has sharply and continuously increased in China, ascending to the first cause of death among all types of cancer.
Yong Chen, Jian-Xin Shi, Xu-Feng Pan, Jian Feng, Heng Zhao   +4 more
doaj   +1 more source

Machine learning models-based on integration of next-generation sequencing testing and tumor cell sizes improve subtype classification of mature B-cell neoplasms

Frontiers in Oncology, 2023
BackgroundNext-generation sequencing (NGS) panels for mature B-cell neoplasms (MBNs) are widely applied clinically but have yet to be routinely used in a manner that is suitable for subtype differential diagnosis.
Yafei Mu, Yafei Mu, Yafei Mu, Yuxin Chen, Yuxin Chen, Yuxin Chen, Yuhuan Meng, Yuhuan Meng, Yuhuan Meng, Tao Chen, Tao Chen, Xijie Fan, Jiecheng Yuan, Jiecheng Yuan, Junwei Lin, Junwei Lin, Jianhua Pan, Jianhua Pan, Jianhua Pan, Guibin Li, Jinghua Feng, Kaiyuan Diao, Yinghua Li, Shihui Yu, Shihui Yu, Shihui Yu, Shihui Yu, Lingling Liu   +27 more
doaj   +1 more source