Results 41 to 50 of about 16,100 (233)

Mutation Spectra of the MRN (MRE11, RAD50, NBS1/NBN) Break Sensor in Cancer Cells

, 2020
The MRN complex (MRE11, RAD50, NBS1/NBN) is a DNA double strand break sensor in eukaryotes. The complex directly participates in, or coordinates, several activities at the break such as DNA resection, activation of the DNA damage checkpoint, chromatin ...
Ruben C. Petreaca, Aman Y. Husbands, Ashton S. Holub, Matthew T. McPherson   +3 more
core   +1 more source

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Nucleic Acids Res., 2010
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136 000 coding mutations in almost 542 000 tumour samples; of the 18 490 genes documented, 4803 (26 ...
S. Forbes, Nidhi Bindal, S. Bamford, C. Cole, C. Kok, D. Beare, Mingming Jia, Rebecca Shepherd, Kenric Leung, A. Menzies, J. Teague, P. Campbell, M. Stratton, P. Futreal   +13 more
semanticscholar   +1 more source

TNFAIP3 mutation may be associated with favorable overall survival for patients with T-cell lymphoma

Cancer Cell International, 2021
Background T-cell lymphoma (TCL) is highly aggressive and has a poor prognosis; thus, it is worth exploring biomarkers that may predict clinical outcomes and investigate their potential role in developing targeted therapies.
Cunte Chen, Zheng Chen, Ling Huang, Lingling Zhou, Lihua Zhu, Sichu Liu, Gengxin Luo, Wenyu Li, Chengwu Zeng, Yangqiu Li   +9 more
doaj   +1 more source

Somatic cancer mutations of LGR6 listed in the COSMIC database as of Jan-2012.

, 2013
Somatic cancer mutations of LGR6 listed in the COSMIC database as of Jan-2012.
Qingyun Liu (322730), Jing Yi (81891), Xing Gong (322727), Kendra S. Carmon (322728), Qiushi Lin (322729), Anthony Thomas (149723)   +5 more
core   +1 more source

Whole-exome sequencing and bioinformatic analyses revealed differences in gene mutation profiles in papillary thyroid cancer patients with and without benign thyroid goitre background

Frontiers in Endocrinology, 2023
BackgroundPapillary thyroid cancer (PTC) is the most common thyroid malignancy. Concurrent presence of cytomorphological benign thyroid goitre (BTG) and PTC lesion is often detected. Aberrant protein profiles were previously reported in patients with and
Zing Hong Eng, Mardiaty Iryani Abdullah, Mardiaty Iryani Abdullah, Khoon Leong Ng, Azlina Abdul Aziz, Nurul Hannis Arba’ie, Nurullainy Mat Rashid, Sarni Mat Junit   +7 more
doaj   +1 more source

Genes having mutations, which were assessed as a high or moderate impact and confirmed in the COSMIC cancer database.

, 2018
Genes having mutations, which were assessed as a high or moderate impact and confirmed in the COSMIC cancer database.
Hideki Tsutsumi (197290), Yoji Sato (164343), Michiyo Nasu (5819729), Takuya Kuroda (164325), Takumi Miura (412321), Akifumi Matsuyama (420978), Takao Hayakawa (214691), Keiko Tano (169945), Akihiro Umezawa (2402), Shinji Kusakawa (164327), Nozomi Takada (158434), Satoshi Yasuda (164326), Satoko Matsuyama (5819726)   +12 more
core   +1 more source

Whole exome sequencing in the rat

BMC Genomics, 2018
Background The rat genome was sequenced in 2004 with the aim to improve human health altered by disease and environmental influences through gene discovery and animal model validation.
Julie F. Foley, Dhiral P. Phadke, Owen Hardy, Sara Hardy, Victor Miller, Anup Madan, Kellie Howard, Kimberly Kruse, Cara Lord, Sreenivasa Ramaiahgari, Gregory G. Solomon, Ruchir R. Shah, Arun R. Pandiri, Ronald A. Herbert, Robert C. Sills, B. Alex Merrick   +15 more
doaj   +1 more source

Abstract 2601: COSMIC-3D: exploring cancer mutations in three dimensions for drug design and discovery

, 2017
Explosions in the availability of cancer genomic data and protein structure data give us the potential to explore cancer molecular biology at an unprecedented scale, and in atomic detail.
Simon Forbes, Harpreet Saini, Harry C. Jubb, Marcel Verdonk   +3 more
core   +1 more source

PanCNV Explorer: A pan-cancer database for copy number variations.

medRxiv
Introduction: Copy number variations (CNVs) are structural genomic alterations that involve changes in the number of copies of specific DNA regions.
Kevin Kornrumpf, Jürgen Dönitz
semanticscholar   +1 more source

Mutational landscape differences between young-onset and older-onset breast cancer patients

BMC Cancer, 2020
Background The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for ...
Nicole E. Mealey, Dylan E. O’Sullivan, Joy Pader, Yibing Ruan, Edwin Wang, May Lynn Quan, Darren R. Brenner   +6 more
doaj   +1 more source