Results 61 to 70 of about 7,424,997 (207)

Mutational profiles of marker genes of cervical carcinoma in Bangladeshi patients

BMC Cancer, 2021
Background Cervical cancer is a gynecologic cancer type that develops in the cervix, accounting for 8% mortality of all female cancer patients. Infection with specific human papillomavirus (HPV) types is considered the most severe risk factor for ...
Shahana Sharmin, Fatima Tuj Zohura, Md. Sajedul Islam, Anika Shimonty, Md. Abdullah-Al-Kamran Khan, Rehana Parveen, Foujia Sharmin, Chowdhury Rafiqul Ahsan, Abul Bashar Mir Md. Khademul Islam, Mahmuda Yasmin   +9 more
doaj   +1 more source

Evaluation of Mutation Risk Using Patient‐Derived Organoids in Patients With Lynch Syndrome

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is a hereditary cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes, most notably associated with colorectal cancer. Although LS patients face high risk of CRC, risk can vary even among those with the same pathogenic MMR germline mutations. We suggest a functional assay platform for
Youmi Shin, Dong Keon Kim, Yoojeong Seo, Hyeon Hee Lee, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Jongwon Oh, Sanghoo Lee, Tae Il Kim   +10 more
wiley   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Somatic Variations in Cervical Cancers in Indian Patients.

PLoS ONE, 2016
There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer.
Poulami Das, Akanksha Bansal, Sudha Narayan Rao, Kedar Deodhar, Umesh Mahantshetty, Shyam K Shrivastava, Karthikeyan Sivaraman, Rita Mulherkar   +7 more
doaj   +1 more source

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Frontiers in Pharmacology, 2019
Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients.
Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin   +13 more
doaj   +1 more source

Identification of differential DNA methylation alterations of ovarian cancer in peripheral whole blood based on within-sample relative methylation orderings

Epigenetics, 2022
Leukocyte cell proportion changes affect the detection of cancer-associated aberrant DNA methylation alterations in peripheral blood samples. We aimed to detect cellular DNA methylation changes in ovarian cancer (OVC) blood samples avoiding the above ...
Hongdong Li, Fengle Jiang, Yuhui Du, Na Li, Zhihong Chen, Hao Cai, You Guo, Guini Hong   +7 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

National Aboriginal and Torres Strait Islander cancer framework 2015 [PDF]

, 2015
Overview The National Aboriginal and Torres Strait Islander Cancer Framework (the Framework) provides high-level guidance and direction for the many individuals, communities, organisations and governments whose combined efforts are required to address ...
Cancer Australia
core  

Cancer bioMarkers database

, 2016
1 TSV (tab-separated values) fileThe cancer bioMarkers database is curated and maintained by several clinical and scientific experts in the field of precision oncology supported by the European Union’s Horizon 2020 funding.
Dienstmann, Rodrigo, Déu Pons, Jordi, Tamborero Noguera, David, Tabernero Cartula, Josep, Rubio Pérez, Carlota, Albanell Mestres, Joan, Vivancos Prellezo, Ana, López Bigas, Núria, González-Pérez, Abel, Schroeder, Michael Philipp, 1986-, Rovira Guerín, Ana, Rodon, Jordi, Tusquets, Ignasi   +12 more
core   +1 more source

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

BMC Public Health
Background Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo   +6 more
doaj   +1 more source