Results 11 to 20 of about 16,100 (233)

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census. [PDF]

PLoS ONE, 2019
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of ...
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell   +6 more
doaj   +3 more sources

A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database

Cancers, 2021
Gliomas are differentiated into two major disease subtypes, astrocytoma or oligodendroglioma, which are then characterized as either IDH (isocitrate dehydrogenase)-wild type or IDH-mutant due to the dramatic differences in prognosis and overall survival.
Ruben C. Petreaca, Renee A. Bouley, Amrit L. Pappula, Shayaan Rasheed, Golrokh Mirzaei   +4 more
core   +2 more sources

Identification of Shared Neoantigens in BRCA1-Related Breast Cancer

Vaccines, 2022
Personalized neoantigen-based cancer vaccines have been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and bring about delays in treatment.
Lucksica Ruangapirom, Nannapat Sutivijit, Chinachote Teerapakpinyo, Apiwat Mutirangura, Chatchanan Doungkamchan   +4 more
doaj   +2 more sources

A first RDF implementation of the COSMIC database on mutations in cancer

EMBnet.journal, 2012
Motivation and Objectives Within a living organism, genome and proteome variations may influence many molecular interactions and biochemical pathways, leading to deleterious effects in the proper activity of cells, tissues, and organs; ultimately, this may be the cause of many syndromes and diseases.
Zappa, Achille, Romano, Paolo
openaire   +3 more sources

Abstract 2599: COSMIC Cancer Gene Census: expert descriptions across genes in oncogenesis

, 2017
The Cancer Gene Census is an ongoing effort to catalogue genes for which somatic mutations have been causally implicated in cancer. The Census comprises manually curated summaries of the most relevant information for cancer-driving genes and their ...
Simon A. Forbes, John Tate, Sally Bamford, Elisabeth Dawson, Peter J. Campbell, Laura Ponting, Raymund Stefancsik, Zbyslaw Sondka, Charlotte G. Cole, Sari A. Ward   +9 more
core   +2 more sources

Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples

BMC Bioinformatics, 2018
Background Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice.
Marcos Díaz-Gay, Maria Vila-Casadesús, Sebastià Franch-Expósito, Eva Hernández-Illán, Juan José Lozano, Sergi Castellví-Bel   +5 more
doaj   +2 more sources

Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation

Frontiers in Oncology
BackgroundHigh-grade colorectal neuroendocrine carcinoma (HCNEC) is a rare but aggressive subset of neuroendocrine tumors. This study was designed to construct a risk model based on comprehensive clinical and mutational genomics data to facilitate ...
Ruixin Wu, Ruixin Wu, Sihao Chen, Sihao Chen, Yi He, Yi He, Ya Li, Song Mu, Aishun Jin, Aishun Jin   +9 more
doaj   +2 more sources

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations [PDF]

PeerJ
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples.
Lihua Wang, Haiyang Sun, Zhenyu Yue, Junfeng Xia, Xiaoyan Li   +4 more
doaj   +3 more sources

Whole-exome sequencing identified mutational profiles of urothelial carcinoma post kidney transplantation

Journal of Translational Medicine, 2022
Kidney transplantation is a lifesaving option for patients with end-stage kidney disease. In Taiwan, urothelial carcinoma (UC) is the most common de novo cancer after kidney transplantation (KT). UC has a greater degree of molecular heterogeneity than do
Lee-Moay Lim, Wen-Yu Chung, Daw-Yang Hwang, Chih-Chuan Yu, Hung-Lung Ke, Peir-In Liang, Ting-Wei Lin, Siao Muk Cheng, A-Mei Huang, Hung-Tien Kuo   +9 more
doaj   +2 more sources

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

BMC Public Health
Background Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo   +6 more
doaj   +2 more sources