Results 141 to 150 of about 205,622 (234)

Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations

Molecules
Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T‐cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational,
Hye Kyung Lee, Gyuhyeok Cho, Jichun Chen, Aaron B. Schultz, Sung‐Gwon Lee, Chengyu Liu, Priscilla A. Furth, Neal S. Young, Jungwook Kim, Alejandro Villarino, Lothar Hennighausen   +10 more
wiley   +1 more source

Mathematical Constraints on Cancer Mutations: Validation of Prime-Fibonacci-Square Framework Across 30 Cancer Types in the COSMIC Database

Mary MacDiarmid
openalex   +2 more sources

The genetic landscape of primary malignant melanoma of the cervix using integrated bioinformatics analysis and whole-exome sequencing. [PDF]

Front Oncol
Zhou J, Xu T, Chen C, Ping Y.
europepmc   +1 more source

MYC Point Mutations in Cancer: A Reboot and a Sequel. [PDF]

Clin Cancer Res
De Luca D, Munafò C, Lorenzi L, Cucco F.   +3 more
europepmc   +1 more source

Interpreting pathways to discover cancer driver genes with Moonlight [PDF]

, 2020
al., et, Bailey, Matthew H., Colaprico, Antonio   +2 more
core   +1 more source

Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations. [PDF]

Hum Genomics
Colin-Leitzinger C, Tang YH, Teng M, Gillis N.   +3 more
europepmc   +1 more source

MOV&RSim: computational modelling of cancer-specific variants and sequencing reads characteristics for realistic tumoral sample simulation. [PDF]

BMC Bioinformatics
Longhin F, Baruzzo G, Hazizaj E, Boscarino D, Paladin D, Di Camillo B.   +5 more
europepmc   +1 more source

Fusions4U: a resource of validated and annotated gene fusions in 328 cancer cell lines. [PDF]

BMC Cancer
Alamshahi A, Persson H.
europepmc   +1 more source