Results 141 to 150 of about 277,677 (243)
Cell Proliferation, EarlyView.To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman +12 more
wiley +1 more source
Statistical method on nonrandom clustering with application to somatic mutations in cancer
BMC Bioinformatics, 2010 Background Human cancer is caused by the accumulation of tumor-specific mutations in oncogenes and tumor suppressors that confer a selective growth advantage to cells.
Rejto Paul A +4 more
doaj +1 more source
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Spitz lesions display a set of genetic alterations that differ from classical melanocytic lesions: examples include mutations in HRAS and fusions involving ALK, ROS1, MET, MAP3K8, BRAF, and the NTRK genes. We present a Spitz spindle cell/Reed nevus with atypical junctional features and an NTRK2 translocation in a patient of unusual age.
Federico Scarfò +5 more
wiley +1 more source
Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. [PDF]
, 2016 Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal evolutionary processes.
Berman, Benjamin P +17 more
core
European Journal of Haematology, EarlyView.ABSTRACT Patients with chronic lymphocytic leukemia (CLL) undergoing ibrutinib treatment often experience incomplete response, yet the molecular level underlying clonal inertia remains to be explored. We investigated the molecular and clinical dynamics of CLL during 16 months of ibrutinib monotherapy by analyzing blood samples from two patients who ...
Sólja Remisdóttir Veyhe +9 more
wiley +1 more source
Impact of cancer mutational signatures on transcription factor motifs in the human genome
BMC Medical Genomics, 2019 Background Somatic mutations in cancer genomes occur through a variety of molecular mechanisms, which contribute to different mutational patterns. To summarize these, mutational signatures have been defined using a large number of cancer genomes, and ...
Calvin Wing Yiu Chan +4 more
doaj +1 more source
The FEBS Journal, EarlyView.N6‐methyladenosine is a key mRNA modification that regulates transcript turnover, translation, and other aspects of RNA fate. The m6A‐demethylase ‘eraser’ enzyme FTO reverses this modification. While FTO is known to promote oncogenic signaling in triple‐negative breast cancer, its wider role across the genome and specific downstream signaling has yet ...
Hidde R. Zuidhof +6 more
wiley +1 more source
Calibration of the Mid-Infrared Tully-Fisher Relation
, 2013 Distance measures on a coherent scale around the sky are required to address the outstanding cosmological problems of the Hubble Constant and of departures from the mean cosmic flow.
Courtois, Helene M. +9 more
core +3 more sources
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction Formalin‐fixed paraffin‐embedded (FFPE) tumor biopsy is the current mainstay of genotyping, but is limited by its invasiveness and tumor heterogeneity. Plasma cell‐free DNA (cfDNA) constitutes a minimally invasive alternative that may better capture tumor‐derived profiles from circulating tumor DNA (ctDNA). This study compares the
Gayaththri Vimalathas +7 more
wiley +1 more source
lncRNASNP2: an updated database of functional SNPs and mutations in human and mouse lncRNAs
Nucleic Acids Res., 2017 Long non-coding RNAs (lncRNAs) are emerging as important regulators in different biological processes through various ways. Because the related data, especially mutations in cancers, increased sharply, we updated the lncRNASNP to version 2 (http ...
Ya-Ru Miao +3 more
semanticscholar +1 more source