Results 11 to 20 of about 186,949 (193)

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census.

PLoS ONE, 2019
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of ...
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell   +6 more
doaj   +2 more sources

COSMIC: a curated database of somatic variants and clinical data for cancer [PDF]

Nucleic Acids Research, 2023
The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer.sanger.ac.uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in cancer, supported by a comprehensive suite of tools for interpreting genomic data ...
Zbysław Sońdka, Nidhi Bindal Dhir, Denise Carvalho‐Silva, S Jupe, Madhumita Madhumita, Stuart McLaren, Mike Starkey, Sari Ward, Jennifer L. Wilding, Madiha Ahmed, Joanna Argasinska, David Beare, Manpreet Singh Chawla, Stephen O. Duke, Ilaria Fasanella, Avirup Guha Neogi, Susan Haller, Balázs Hetényi, Leonie Hodges, Alexander Holmes, Rachel Lyne, Thomas Maurel, Sumodh Nair, Helder Pedro, Amaia Sangrador‐Vegas, Helen Schuilenburg, Zoe Sheard, Siew Yit Yong, Jon W. Teague   +28 more
openalex   +2 more sources

COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets [PDF]

Briefings Bioinform., 2021
Mutations in hallmark genes are believed to be the main drivers of cancer progression. These mutations are reported in the Catalogue of Somatic Mutations in Cancer (COSMIC).
Ali F. Alsulami, Pedro Henrique Monteiro Torres, Ismail Moghul, S.M. Arif, Amanda K. Chaplin, Sundeep Chaitanya Vedithi, Tom L. Blundell   +6 more
openalex   +2 more sources

Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population

BMC Medical Genomics, 2022
Purpose To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population in real-world. Methods We analyzed PIK3CA mutation status in sequencing data of cell-free DNA from plasma and genomic DNA from matched ...
Qingfeng Huang, Yang Zhou, Bowen Wang, Yi Zhao, Fengxia Zhang, Bowen Ding   +5 more
doaj   +2 more sources

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations [PDF]

PeerJ
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples.
Lihua Wang, Haiyang Sun, Zhenyu Yue, Junfeng Xia, Xiaoyan Li   +4 more
doaj   +3 more sources

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

BMC Public Health
Background Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo   +6 more
doaj   +2 more sources

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website [PDF]

British Journal of Cancer, 2004
The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue.
Sally Bamford, Elisabeth Dawson, Simon Forbes, Jody Clements, Roger Pettett, Ahmet Doǧan, Adrienne M. Flanagan, Jon W. Teague, PA Futreal, Michael R. Stratton, Richard Wooster   +10 more
openalex   +2 more sources

Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation

Frontiers in Oncology
BackgroundHigh-grade colorectal neuroendocrine carcinoma (HCNEC) is a rare but aggressive subset of neuroendocrine tumors. This study was designed to construct a risk model based on comprehensive clinical and mutational genomics data to facilitate ...
Ruixin Wu, Ruixin Wu, Sihao Chen, Sihao Chen, Yi He, Yi He, Ya Li, Song Mu, Aishun Jin, Aishun Jin   +9 more
doaj   +2 more sources

Predictive Modeling of Novel Somatic Mutation Impacts on Cancer Prognosis: A Machine Learning Approach Using the COSMIC Database [PDF]

medRxiv
Masab Mansoor
openalex   +2 more sources

An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

Discover Oncology
Background To explore the role of GAB2 in pan-cancer based on bioinformatics analysis. Methods Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer.
Yi Yin, Yong Li, Yaoyang Zhang, Qiucheng Jia, Huiming Tang, Jiming Chen, Rui Ji   +6 more
doaj   +2 more sources