Results 11 to 20 of about 184,107 (180)

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census.

PLoS ONE, 2019
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of ...
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell   +6 more
doaj   +2 more sources

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations [PDF]

PeerJ
Most computational methods for predicting driver mutations have been trained using positive samples, while negative samples are typically derived from statistical methods or putative samples.
Lihua Wang, Haiyang Sun, Zhenyu Yue, Junfeng Xia, Xiaoyan Li   +4 more
doaj   +3 more sources

Identification of Shared Neoantigens in BRCA1-Related Breast Cancer

Vaccines, 2022
Personalized neoantigen-based cancer vaccines have been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and bring about delays in treatment.
Lucksica Ruangapirom, Nannapat Sutivijit, Chinachote Teerapakpinyo, Apiwat Mutirangura, Chatchanan Doungkamchan   +4 more
doaj   +2 more sources

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

BMC Public Health
Background Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo   +6 more
doaj   +2 more sources

Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation

Frontiers in Oncology
BackgroundHigh-grade colorectal neuroendocrine carcinoma (HCNEC) is a rare but aggressive subset of neuroendocrine tumors. This study was designed to construct a risk model based on comprehensive clinical and mutational genomics data to facilitate ...
Ruixin Wu, Ruixin Wu, Sihao Chen, Sihao Chen, Yi He, Yi He, Ya Li, Song Mu, Aishun Jin, Aishun Jin   +9 more
doaj   +2 more sources

Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

Molecules
The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +2 more sources

An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

Discover Oncology
Background To explore the role of GAB2 in pan-cancer based on bioinformatics analysis. Methods Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer.
Yi Yin, Yong Li, Yaoyang Zhang, Qiucheng Jia, Huiming Tang, Jiming Chen, Rui Ji   +6 more
doaj   +2 more sources

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Frontiers in Pharmacology, 2019
Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients.
Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin   +13 more
doaj   +2 more sources

Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer

Frontiers in Oncology
BackgroundThe role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear.MethodsIntegrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases ...
Xue Jiang, Xue Jiang, Xiaobin Wu, Manjiao Lu, Wenna Fan, Jing Song, Fangzhou Song   +6 more
doaj   +2 more sources

Unravelling the instability of mutational signatures extraction via archetypal analysis

Frontiers in Genetics, 2023
The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts.
Corrado Pancotti, Cesare Rollo, Giovanni Birolo, Silvia Benevenuta, Piero Fariselli, Tiziana Sanavia   +5 more
doaj   +1 more source