Results 11 to 20 of about 194,869 (207)

Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census.

PLoS ONE, 2019
Genomics and genome screening are proving central to the study of cancer. However, a good appreciation of the protein structures coded by cancer genes is also invaluable, especially for the understanding of functions, for assessing ligandability of ...
Sony Malhotra, Ali F Alsulami, Yang Heiyun, Bernardo Montano Ochoa, Harry Jubb, Simon Forbes, Tom L Blundell   +6 more
doaj   +2 more sources

Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population

BMC Medical Genomics, 2022
Purpose To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population in real-world. Methods We analyzed PIK3CA mutation status in sequencing data of cell-free DNA from plasma and genomic DNA from matched ...
Qingfeng Huang, Yang Zhou, Bowen Wang, Yi Zhao, Fengxia Zhang, Bowen Ding   +5 more
doaj   +2 more sources

Identification of Shared Neoantigens in BRCA1-Related Breast Cancer

Vaccines, 2022
Personalized neoantigen-based cancer vaccines have been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and bring about delays in treatment.
Lucksica Ruangapirom, Nannapat Sutivijit, Chinachote Teerapakpinyo, Apiwat Mutirangura, Chatchanan Doungkamchan   +4 more
doaj   +2 more sources

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

BMC Public Health
Background Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants ...
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo   +6 more
doaj   +2 more sources

An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective

Discover Oncology
Background To explore the role of GAB2 in pan-cancer based on bioinformatics analysis. Methods Based on TCGA and GTEx databases, we used TIMER2.0 online analysis tool and R language to analyze the expression of GAB2 in pan-cancer.
Yi Yin, Yong Li, Yaoyang Zhang, Qiucheng Jia, Huiming Tang, Jiming Chen, Rui Ji   +6 more
doaj   +2 more sources

Cancer-Related Mutations in the Sam Domains of EphA2 Receptor and Ship2 Lipid Phosphatase: A Computational Study

Molecules
The lipid phosphatase Ship2 interacts with the EphA2 receptor by forming a heterotypic Sam (sterile alpha motif)–Sam complex. Ship2 works as a negative regulator of receptor endocytosis and consequent degradation, and anti-oncogenic effects in cancer ...
Marian Vincenzi, Flavia Anna Mercurio, Ida Autiero, Marilisa Leone   +3 more
doaj   +2 more sources

Pathway Based Analysis of Mutation Data Is Efficient for Scoring Target Cancer Drugs

Frontiers in Pharmacology, 2019
Despite the significant achievements in chemotherapy, cancer remains one of the leading causes of death. Target therapy revolutionized this field, but efficiencies of target drugs show dramatic variation among individual patients.
Marianna A. Zolotovskaia, Marianna A. Zolotovskaia, Maxim I. Sorokin, Maxim I. Sorokin, Maxim I. Sorokin, Anna A. Emelianova, Nikolay M. Borisov, Nikolay M. Borisov, Denis V. Kuzmin, Pieter Borger, Andrew V. Garazha, Anton A. Buzdin, Anton A. Buzdin, Anton A. Buzdin   +13 more
doaj   +2 more sources

Long non-coding RNA FAM87A is associated with overall survival and promotes cell migration and invasion in gastric cancer

Frontiers in Oncology
BackgroundThe role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear.MethodsIntegrating transcriptome data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases ...
Xue Jiang, Xue Jiang, Xiaobin Wu, Manjiao Lu, Wenna Fan, Jing Song, Fangzhou Song   +6 more
doaj   +2 more sources

Papillary Renal Cell Carcinoma: Demographics, Survival Analysis, Racial Disparities, and Genomic Landscape

Journal of Kidney Cancer and VHL, 2023
Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of renal cell cancer. This research aims to present a large database study highlighting the demographic, clinical, and pathological factors, racial disparities ...
Asad Ullah, Abdul Qahar Khan Yasinzai, Naema Daino, Bisma Tareen, Zulfiqar Haider Jogezai, Haleema Sadia, Nimra Jamil, Girahnaz Baloch, Adil Karim, Kaleemullah Badini, Agha Wali, Abdul Waheed, Marjan Khan, Bina Asif, Kaleemullah Kakar, Saleh Heneidi, Feroze Sidhwa, Nabin R Karki   +17 more
doaj   +1 more source

The potential, analysis and prospect of ctDNA sequencing in hepatocellular carcinoma [PDF]

PeerJ, 2022
Background The genome map of hepatocellular carcinoma (HCC) is complex. In order to explore whether circulating tumor cell DNA (ctDNA) can be used as the basis for sequencing and use ctDNA to find tumor related biomarkers, we analyzed the mutant genes of
Yubo Ding, Jingwei Yao, Meiling Wen, Xiong Liu, Jialu Huang, Minghui Zhang, Yu Zhang, Yufan Lv, Zhuoyi Xie, JianHong Zuo   +9 more
doaj   +2 more sources