Results 201 to 210 of about 16,100 (233)

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC

Veterinary and Comparative Oncology, 2023
Sharadha Sakthikumar, Salvatore J Facista, Derick Whitley   +2 more
exaly   +2 more sources

Abstract 4312: Identification of shared mutations across many parallel human and canine cancers based on comprehensive survey of canine cancer mutations and the “caninization” of human mutations from COSMIC

Cancer Research, 2023
Introduction: Vidium Insight™ is a canine cancer genomic biomarker database built from exhaustive curation of peer-reviewed literature describing genomic mutations in canine cancers.
Sharadha Sakthikumar, Salvatore J. Facista, Derick Whitley, Manisha Warrier, William P. D. Hendricks, Guannan Wang   +5 more
semanticscholar   +1 more source

COSMIC: High‐Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer

Current Protocols in Human Genetics, 2016
E Dawson
exaly   +2 more sources

Abstract 5028: Integration of molecular data into cancer patient database

Cancer Research, 2022
Background: Precision medicine holds promise of being a more effective method for treating complex diseases such as cancer. Nuanced care is needed, as the development and clinical course of cancer is multifactorial with influences from the general ...
Basil H. Chaballout, Avery T. Funkhouser, Bailey B Blair, Jane Goodwin, Alexander M Strigenz, C. Arthur, Julie C. Martin, W. Edenfield, Anna V. Blenda   +8 more
semanticscholar   +1 more source

Annotating Whole Genome Sequencing in COSMIC (The Catalogue of Somatic Mutations in Cancer)

Nature Precedings, 2010
"COSMIC, the Catalogue Of Somatic Mutations In Cancer":http://www.sanger.ac.uk/cosmic is designed to store and display somatic mutation information relating to human cancers, combining detailed information on publications, samples and mutation ...
M Jia, N Bindal, S A Forbes, P A Futreal, K Leung, R Shepherd, J Teague, C Y Kok, A Menzies, M R Stratton, D Breare, C G Cole, S Bamford   +12 more
exaly   +3 more sources

In silico analysis of COSMIC retrieved P body gene mutations in breast cancer

, 2020
P bodies (Processing bodies) are mRNP granules and are involved in mRNA decay, gene silencing by miRNA or siRNA, deadenylation and decapping. These are dynamic and shuttle their components with stress granules, ribosomes and stalled mRNAs within them can
Aswathi Paleri, Isaac Cherian, P. Suresh, T. Venkatesh   +3 more
semanticscholar   +1 more source

Abstract 906: COSMIC: Describing the world’s knowledge of somatic mutations in cancer

Bioinformatics, Convergence Science, and Systems Biology, 2019
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk/cosmic) is a continual effort to integrate all available information on somatic mutations and other molecular alterations causing every form of human cancer. Being the world’
S. Forbes, D. Beare, charalampos boutselakis, S. Bamford, Kate Noble, Claire E. Rye, J. Tate, C. Kok, Charlie Hathaway, Laura Ponting, Chris Ramshaw, Raymund Stefancsik, Sam L. Thompson, Bhavana Harsha, Nidhi Bindal, Shicai Wang, S. Jupe, H. Speedy, C. Creatore, Peter Fish, Sari Ward, C. Cole, E. Dawson, Zbyslaw Sondka   +23 more
semanticscholar   +1 more source

Autophagy promotes the acquisition of genotoxic resistance in cancer cells in a paracrine manner via upregulation of PLK1-RAD9A axis.

Journal of Biochemistry (Tokyo)
Autophagy suppresses tumorigenesis in normal cells, but in established tumors, it can promote tumor progression, particularly by enhancing resistance to stress. However, the mechanism underlying this tumor-promoting function remains unclear.
M. Ikura, Takuma Shiraki, T. Ikura, Kanji Furuya   +3 more
semanticscholar   +1 more source

Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting

Research Square
Rare and short-lived DNA conformations are proposed to be key drivers of mutagenesis, yet assessing their contribution to mutational signatures found in human cancers remains challenging.
Hashim M. Al-Hashimi, Or Szekely, Yeongjoon Lee, A. Rangadurai, S. Guseva, Joshua Cooksey, Edgar M. Faison, Nikita Zalenski, Qi Zhang, Zucai Suo   +9 more
semanticscholar   +1 more source

A Cancer Treatment Plan Recommendation System Based on Whole Genome Sequencing Data of Cancer Tissues *

Systems and Information Engineering Design Symposium
With the continuous development of gene sequencing technology, new targets for cancer treatment are constantly being discovered. To help oncologists develop corresponding treatment plans based on the results of gene sequencing of cancer tissues, this ...
Andrew Zheng, Wenqiang Chen, Bin Li
semanticscholar   +1 more source