Results 91 to 100 of about 14,844 (293)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović   +11 more
wiley   +1 more source

Plasmakristall‐4 Experiment: 10 Years of Operation in Orbit

open access: yesContributions to Plasma Physics, EarlyView.
ABSTRACT Plasmakristall‐4 (PK‐4) is a microgravity complex plasma laboratory operated for 10 years on board the International Space Station. Its main purpose is the particle‐resolved investigation of generic condensed matter phenomena using strongly coupled suspensions of microparticles immersed in low‐pressure gas‐discharge plasmas.
M. Pustylnik   +3 more
wiley   +1 more source

Neighborhood Disadvantage and Comorbid Mental Health Conditions in Adolescents and Young Adults With Eating Disorders

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anxiety and depression are highly prevalent among adolescents and young adults with eating disorders. A comorbid mental health condition is associated with worsened long‐term eating disorder outcomes. While individual risk factors for comorbid anxiety or depression and eating disorders have been elucidated, the impact of external ...
Anita V. Chaphekar   +3 more
wiley   +1 more source

Water Electrolysis Technologies for Extraterrestrial Water Resource Conversion

open access: yesEcoEnergy, EarlyView.
This paper reviews four water electrolysis technologies for extraterrestrial water conversion: alkaline water electrolysis, proton exchange membrane water electrolysis, solid oxide water electrolysis, and anion exchange membrane water electrolysis. It elaborates on their mechanisms, components, and integration, highlighting challenges such as water ...
Yawen Jiang   +6 more
wiley   +1 more source

Numerical and Experimental Evaluation of a Simplified Lateral Spring Formulation for Rocking Structures

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Rocking podium isolation systems have gained significant research interest as a method of limiting seismic demands on superstructures and eliminating residual post‐earthquake drifts through self‐centring behaviour. However, while numerous models of varying complexity, including analytical, phenomenological, and physical formulations, have been
Marawan Zaki   +2 more
wiley   +1 more source

A Topological Investigation of the Cosmic Web Formation

open access: yesEdinburgh Student Journal of Science
N-body simulations of the evolution of the large-scale structure of the universe (the Cosmic Web) were run while altering attractive gravity laws and initial conditions, in order to infer which properties of the universe are revealed by its current large-
Eva Staikou, Marcos Pellejero
doaj   +1 more source

Preliminary Investigation of Effort Expenditure for Food and Monetary Rewards in Loss‐of‐Control Eating

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Background Loss‐of‐control eating (LOCE) is present across multiple eating disorder (ED) diagnoses and is associated with greater eating pathology in the general population. Initial research suggests differences in motivation to approach rewards in individuals with LOCE, but few studies directly compare disorder‐relevant and general rewards ...
Sarah C. Dolan   +5 more
wiley   +1 more source

Trading oxygen for iron

open access: yesAstronomy & Astrophysics
Due to their different nucleosynthetic origin, a stellar population produces oxygen (O) and iron (Fe) on different timescales, and their relative abundance can deviate strongly from solar.
Chruślińska M.   +6 more
doaj   +1 more source

Evolution of interior entropy of a loop quantum-corrected black hole pierced by a cosmic string

open access: yesPhysics Letters B
The concept of interior entropy of black hole provides a possible way to deal with information problem. We derive evolution relation between interior entropy and Bekenstein-Hawking entropy for a loop quantum-corrected black hole with large mass pierced ...
Wei Zhang
doaj   +1 more source

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