Results 171 to 180 of about 12,121 (264)

Prior therapy defines mutation profiles in childhood cancer at relapse. [PDF]

Nature
Layeghifard M, Díaz-Gay M, Bergstrom EN, Mahendralingam MJ, Light N, Blay S, Nash JO, Anderson ND, Au JN, Davidson S, Ballester PL, Wen T, Daud SK, Edward LM, Ashiqul Islam SM, Khandekar A, Otlu B, Brunga L, Hammad R, Nassif S, Thacker NH, Feltham T, Fuentes-Bolanos NA, Wong-Erasmus M, Levine MF, Miller KE, Shukla NN, Kinnaman MD, Glodzik D, Portwine C, Millson S, Zorzi AP, Mikhail M, Fernandez CV, Wheaton L, Gundem G, Kung AL, Tabori U, Mayoh C, Papaemmanuil E, Cowley MJ, Malkin D, Villani A, Alexandrov LB, Shlien A.   +44 more
europepmc   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Evaluating Somatic Mutational Contamination in Large-Scale Germline Genomic Studies. [PDF]

Biology (Basel)
Ji X, Bai X, He G, Yan K, Wang E, Tang YD, Chen L, Cui Q.   +7 more
europepmc   +1 more source

Elucidating PI3K/AKT/PTEN Pathway Alterations at Single‐Cell Level in CTCs From HR+/HER2− Metastatic Breast Cancer

Cancer Science, EarlyView.
Single CTC analysis revealed extensive inter‐ and intra‐patient heterogeneity of PI3K/AKT/PTEN pathway alterations in HR+/HER2− metastatic breast cancer, capturing both SNVs and CNAs, including PTEN loss‐of‐function events. Longitudinal CTC profiling also uncovered dynamic clonal evolution, highlighting its potential to complement tissue and ctDNA ...
Tania Rossi, Michela Palleschi, Caterina Gianni, Filippo Merloni, Alessandra Virga, Sara Bandini, Davide Angeli, Michela Tebaldi, Roberta Maltoni, Paola Ulivi, Antonino Musolino   +10 more
wiley   +1 more source

Physics-Constrained Reconstructions of Sunspot Number from Millennial-Scale Annual Heliospheric Modulation Potential. [PDF]

Sol Phys
Saha C, Owens M, Lockwood M, Barnard L, Brehm N, Dalla S, Herbst K, Muscheler R, Wang J.   +8 more
europepmc   +1 more source

Dynamic Changes of ctDNA‐Based MRD and Genomic Mutations Predict Prognosis in ESCC Treated With Definitive Radiotherapy

Cancer Science, EarlyView.
In patients with esophageal squamous cell carcinoma receiving definitive radiotherapy combined with systemic therapy, posttreatment TP53 mutation clearance and ctDNA‐MRD negativity predict favorable outcomes, whereas persistent ctDNA signals indicate elevated relapse risk, supporting nucleosome‐ and MRD‐informed surveillance and risk‐stratification ...
Shutang Liu, Qi Wang, Chun Han, Xiaoning Li, Rutian Cheng, Lihong Liu, Hua Dong, Xuejiao Ren, Shuman Zhen, Lan Wang   +9 more
wiley   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer. [PDF]

Cancer Rep (Hoboken)
Manav N, Kashyap A, Malhotra L, Rajegowda C, Prasad CP.   +4 more
europepmc   +1 more source

Assessment of MRD and Longitudinal Monitoring of Post‐Surgery Biliary Tract Cancer With a Customized ctDNA Panel

Cancer Science, EarlyView.
A customized panel was established for BTC MRD detection. Preoperative ctDNA detection was associated with pathological stage and poorer RFS and OS. Longitudinal monitoring detected ctDNA before radiological recurrence in 72.7% of patients, with a median lead time of 77 days, supporting ctDNA as a complementary prognostic biomarker with CA19‐9 ...
Yoshihito Shinohara, Toru Nakamura, Yasutoshi Kimura, Takeshi Murakami, Shigeyuki Kojima, Toshikazu Yamaguchi, Kanako C. Hatanaka, Ryo Okazaki, Yosuke Kitayama, Keita Fukuda, Fabio Pittella‐Silva, Yusuke Nakamura, Satoshi Hirano, Siew‐Kee Low   +13 more
wiley   +1 more source

Utilizing BERTopic modeling for concept discovery in the domain of gerotranscendence and solitude. [PDF]

J Biomed Semantics
Jesudas BD, Wilson F, Mavrovich RA, Kindya S, Yeh FY, Smith S, Ravenel J, Zheng J, He Y, Reischer HN, Bowker JC, Beverley J, Duncan WD.   +12 more
europepmc   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source