Results 131 to 140 of about 409 (199)
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CHOOSING A COSOLVENT: SOLUBILIZATION OF NAPHTHALENE AND COSOLVENT PROPERTY
Environmental Toxicology and Chemistry, 1996Abstract The addition of an organic cosolvent to water can increase the aqueous solubility of many hydrophobic organic compounds (HOCs). This work examines the correlations between the change of naphthalene solubility and various physicochemical properties of the cosolvent added to the system.
An Li +2 more
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International Journal of Pharmaceutics, 1999
Previously published cosolvency models are critically evaluated in terms of their ability to mathematically correlate solute solubility in binary solvent mixtures as a function of solvent composition. Computational results show that the accuracy of the models is improved by increasing the number of curve-fit parameters.
William E Acree
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Previously published cosolvency models are critically evaluated in terms of their ability to mathematically correlate solute solubility in binary solvent mixtures as a function of solvent composition. Computational results show that the accuracy of the models is improved by increasing the number of curve-fit parameters.
William E Acree
exaly +4 more sources
Cosolvent Assisted Protein Refolding
Nature Biotechnology, 1990The use of cosolvents in aqueous systems has been shown to enhance protein refolding and decrease aggregation. In this study, we have used polyethylene glycol (PEG) in the molecular weight range of 1000 to 8000 Daltons to effectively increase the rate of refolding and prevent aggregation of the model protein, bovine carbonic anhydrase B (CAB).
J L, Cleland, D I, Wang
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Polymer Bulletin, 1991
By a series of quaternization and amidoalkylation reactions, polymers based on microporous poly(styrene-co-divinylbenzene-), and containing quaternary ammonium groups (Q) and carboxamide groups (L) imitating polar aprotic solvents (DMA c and NMP) are prepared.
Hana Hrudkov�, V�clav Janout
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By a series of quaternization and amidoalkylation reactions, polymers based on microporous poly(styrene-co-divinylbenzene-), and containing quaternary ammonium groups (Q) and carboxamide groups (L) imitating polar aprotic solvents (DMA c and NMP) are prepared.
Hana Hrudkov�, V�clav Janout
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Excluded Cosolvent in Chromatography
Journal of Pharmaceutical Sciences, 2018The concept of cosolvent exclusion was developed by a group of Timasheff's laboratory in 1970-1990 and is currently used widely to explain the effects of a variety of cosolvents on the stability and solubility of macromolecules. Not surprisingly, these concepts have had substantial influence in the fields of formulation, protein folding and unfolding ...
Tsutomu, Arakawa, Pete, Gagnon
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Die Makromolekulare Chemie, 1981
AbstractSeveral cosolvent mixtures for PMMA are reported. Their cosolvency has been confirmed by studying phase separation temperatures as a function of solvent composition. The results show that they are very powerful cosolvents. Acetonitrile forms such cosolvent mixtures with compounds containing different chemical groups (ester, ketone, alcohol ...
Inés Fernández‐Piérola +1 more
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AbstractSeveral cosolvent mixtures for PMMA are reported. Their cosolvency has been confirmed by studying phase separation temperatures as a function of solvent composition. The results show that they are very powerful cosolvents. Acetonitrile forms such cosolvent mixtures with compounds containing different chemical groups (ester, ketone, alcohol ...
Inés Fernández‐Piérola +1 more
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Polymer Bulletin, 1984
Etude de polymethacrylate de phenyle polymethacrylate de (tetramethyl-1,1,3,3 butyl) phenyle et de poly-t-butyl-4 styrene dans le melange THF ...
GARGALLO, L, RIOS, H, RADIC, D
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Etude de polymethacrylate de phenyle polymethacrylate de (tetramethyl-1,1,3,3 butyl) phenyle et de poly-t-butyl-4 styrene dans le melange THF ...
GARGALLO, L, RIOS, H, RADIC, D
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Cosolvent Effects on Protein Stability
Annual Review of Physical Chemistry, 2013Proteins are marginally stable, and the folding/unfolding equilibrium of proteins in aqueous solution can easily be altered by the addition of small organic molecules known as cosolvents. Cosolvents that shift the equilibrium toward the unfolded ensemble are termed denaturants, whereas those that favor the folded ensemble are known as protecting ...
Deepak R, Canchi, Angel E, García
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Cosolvent control of substrate inhibition in cosolvent stimulation of β-glucuronidase activity
Biochemical and Biophysical Research Communications, 1977Abstract Bacterial β-glucuronidase exhibits a considerable increase in specific activity, upon addition of suitable organic cosolvents to aqueous systems. The effect is especially marked with three to five carbon alcohols; a nine fold increase was observed in this study using t-butanol in the range of 10% by volume of t-butanol in water.
P S, Pesheck, R E, Lovrien
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Understanding the Cosolvation Effect of Dendrimers
Journal of Chemical Theory and Computation, 2005Molecules that are virtually insoluble in certain solvents may be uploaded to "hostile" phases by dendrimers. Prime examples of this phenomenon are Eosin Y, EY, and Rose Bengal, RB, that are not soluble in CH2Cl2 where they can, however, be solvated through the interaction with a fourth generation dendrimer of polypropylene amine, POPAM-4D.
TEOBALDI, GILBERTO +2 more
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