Results 51 to 60 of about 1,544,528 (352)
The EMBO Reports, 2000 Order is the key word of science. Scientists have tried to order and explain all the phenomena of the universe. They found that the planets and stars move along predictable paths, discovered the laws of gravitation and devised formulae to describe inheritance. For them, the universe is like a clock.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Cost-benefit analysis of flight extended operations (ETOPS) for Garuda Indonesia airways
SHS Web of Conferences, 2018 Garuda Indonesia reducing the flight cost used flight extended operations (ETOPS). ETOPS can reduce travel time and fuel consumption. The cost-benefit analysis was conducted to compare the flight between NON ETOPS flight and ETOPS flight Cengkareng ...
Purwaningsih Ratna +2 more
doaj +1 more source
, 2020 Cost - benefit analysis (CBA) is a method that is used for making investment decisions in public and private sector, and comparing benefits and costs resulting from the investments. This method attempts to determine present value of potential benefits and costs of any intended investment, and selects the project with the most benefits by comparing ...
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cost Benefit Analysis of Sports Medicine Team Coverage
Orthopaedic Journal of Sports Medicine, 2013 Objectives: Coverage of high school athletic football by orthopaedic sports medicine specialists is considered standard of care in many localities. Taking time away from an orthopaedic practice to provide on field athletic care has potential advantages ...
Fotios P. Tjoumakaris MD +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Cost benefit analysis for failure of sewer pipelines
MATEC Web of Conferences, 2017 Sewer pipelines failure in sewage networks can have adverse potential impacts on socio-economic aspects in any community. Due to the fact that it’s difficult to capture the relationship between the physical and economical aspects as a result of critical ...
Elmasry Mohamed +2 more
doaj +1 more source