Results 51 to 60 of about 27,110,461 (296)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A Cost–benefit Analysis of Continuous Assessment
Proceedings of the 7th International Conference on Computer Supported Education, 2015 Peer ...
Duch Brown, Amalia +4 more
openaire +3 more sources
, 2021 https://www.benefitcostanalysis.org/index.php?option=com_dailyplanetblog&view=entry&year=2021&month=03&day=22&id=69:on-balance-efficiency-without-apology-consideration-of-the-marginal-excess-tax-burden-and-distributional-impacts-in-benefit-cost ...
Greenberg, David
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Economic Evaluation of Health Interventions: A Critical Review
Iranian Journal of Public Health, 2022 Background: Economic evaluation is used for the optimal allocation of resources in the health sector. While a large number of economic evaluation studies have been conducted, there is less critical review of these studies.
Ali Mohammad Mosadeghrad +2 more
doaj
The EMBO Reports, 2000 Order is the key word of science. Scientists have tried to order and explain all the phenomena of the universe. They found that the planets and stars move along predictable paths, discovered the laws of gravitation and devised formulae to describe inheritance. For them, the universe is like a clock.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Incremental expenditure for hospital care associated infections [PDF]
Al Ameen Journal of Medical Sciences, 2019 Background: Hospital care associated infections [HAI] are time varying and they substantially increase the burden for the patients, relatives, Payers, Third party Administrators and Hospital Administrators.
K.S. Sarala +2 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Cost-benefit analysis of flight extended operations (ETOPS) for Garuda Indonesia airways
SHS Web of Conferences, 2018 Garuda Indonesia reducing the flight cost used flight extended operations (ETOPS). ETOPS can reduce travel time and fuel consumption. The cost-benefit analysis was conducted to compare the flight between NON ETOPS flight and ETOPS flight Cengkareng ...
Purwaningsih Ratna +2 more
doaj +1 more source