Results 61 to 70 of about 27,110,461 (296)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Cost Benefit Analysis of Sports Medicine Team Coverage
Orthopaedic Journal of Sports Medicine, 2013 Objectives: Coverage of high school athletic football by orthopaedic sports medicine specialists is considered standard of care in many localities. Taking time away from an orthopaedic practice to provide on field athletic care has potential advantages ...
Fotios P. Tjoumakaris MD +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Cost benefit analysis for failure of sewer pipelines
MATEC Web of Conferences, 2017 Sewer pipelines failure in sewage networks can have adverse potential impacts on socio-economic aspects in any community. Due to the fact that it’s difficult to capture the relationship between the physical and economical aspects as a result of critical ...
Elmasry Mohamed +2 more
doaj +1 more source
Does Mitigation Save? Reviewing cost-1 benefit analyses of disaster risk reduction [PDF]
, 2014 The benefit-cost-ratio (BCR), used in cost-benefit analysis (CBA), is an indicator that attempts to summarize the overall value for money of a project.
Shreve, Cheney +6 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
COST BENEFIT ANALYSIS OF COMPROMISING LEDGER SYSTEM BASED ON BLOCKCHAIN TECHNOLOGY
BizInfo, 2018 Modern application of the blockchain technology is the center of attention of technology and economy sectors. Proper usage of blockchain is based on peer to peer (P2P) network to coordinate a worldwide, universal ledger where all transactions on the ...
Edis Mekić +2 more
doaj +1 more source
PRINCIPLES OF COST-BENEFIT ANALYSIS [PDF]
This paper summarizes the procedure for the economic evaluation of government projects and policy reforms. It begins with the social welfare function underpinnings of cost-benefit analysis including the role of distributive weights and the choice of ...
Robin Boadway
core
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source