Results 71 to 80 of about 3,050,053 (318)

Benefit-cost analysis of participatory breeding program in Syria [PDF]

open access: yes, 2016
Participatory plant breeding is seen by several scientists as a way to overcome the limitations of conventional breeding by offering farmers the possibility of deciding which varieties better suit their needs and conditions without exposing them to any
Ceccarelli, Salvatore   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Cost-benefit analysis of moving-target defense in power grids [PDF]

open access: yes, 2018
We study moving-target defense (MTD) that actively perturbs transmission line reactances to thwart stealthy false data injection (FDI) attacks against state estimation in a power grid.
Lakshminarayana, Subhash   +1 more
core   +1 more source

Cost-Benefit Analysis

open access: yes, 2014
This chapter summarises the major steps used in CBA. It includes a discussion of incremental cost-comparison analysis, the optimal choice of programme and incremental cost-analysis. Nine steps are identified and described: (1) specifying alternatives, (2) deciding whose costs and benefits to include, (3) deciding what costs to count, (4) identifying ...
openaire   +3 more sources

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Cost-benefit analysis of aquaculture breeding programs

open access: yesGenetics Selection Evolution, 2018
Background Profitability of breeding programs is a key determinant in the adoption of selective breeding, and can be evaluated using cost-benefit analysis. There are many options to design breeding programs, with or without a multiplier tier.
Kasper Janssen   +2 more
doaj   +1 more source

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