Results 41 to 50 of about 2,295,725 (356)

Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative

British medical journal, 2017
Objectives To evaluate the impact of total knee replacement on quality of life in people with knee osteoarthritis and to estimate associated differences in lifetime costs and quality adjusted life years (QALYs) according to use by level of symptoms ...
B. Ferket, Zach M. Feldman, Jing Zhou, E. Oei, S. Bierma-Zeinstra, M. Mazumdar   +5 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Economic Evaluation of Health Interventions: A Critical Review

Iranian Journal of Public Health, 2022
Background: Economic evaluation is used for the optimal allocation of resources in the health sector. While a large number of economic evaluation studies have been conducted, there is less critical review of these studies.
Ali Mohammad Mosadeghrad, Ebrahim Jaafaripooyan, Mahmoud Zamandi   +2 more
doaj  

Decision Analysis and Cost-Effectiveness Analysis [PDF]

Seminars in Spine Surgery, 2009
Healthcare decision-making can be complex, often requiring decision makers to weigh serious trade-offs, consider patients' values, and incorporate evidence in the face of uncertainty. Medical decisions are made implicitly by clinicians and other decision-makers on a daily basis. Decisions based largely on personal experience are subject to many biases.
Jon D. Lurie, Anna N.A. Tosteson, Christene M. McDonough, Christene M. McDonough, Hilary F. Ryder   +4 more
openaire   +3 more sources

Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis.

Health Technology Assessment, 2017
BACKGROUND Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of thromboembolic events. Anticoagulation therapy to prevent AF-related stroke has been shown to be cost-effective.
N. Welton, A. McAleenan, H. Thom, P. Davies, W. Hollingworth, J. Higgins, G. Okoli, J. Sterne, G. Feder, D. Eaton, A. Hingorani, C. Fawsitt, T. Lobban, P. Bryden, A. Richards, R. Sofat   +15 more
semanticscholar   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Cost–Effectiveness Analysis in Pharmacogenomics [PDF]

Pharmacogenomics, 2010
The existence of finite healthcare budgets drives the need to consider opportunity cost and demonstrate that pharmacogenomic interventions offer added value, in terms of the relative costs and benefits, compared with current practice. This is where the framework of cost-effectiveness analysis is useful.
Katherine Payne, FH Shabaruddin
openaire   +3 more sources

Extended Cost-Effectiveness Analysis for Health Policy Assessment: A Tutorial

PharmacoEconomics (Auckland), 2016
Health policy instruments such as the public financing of health technologies (e.g., new drugs, vaccines) entail consequences in multiple domains. Fundamentally, public health policies aim at increasing the uptake of effective and efficient interventions
S. Verguet, Jane J. Kim, D. Jamison
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source