Results 51 to 60 of about 1,759,003 (381)
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Basal Insulin Regimens for Adults with Type 1 Diabetes Mellitus : A Cost-Utility Analysis [PDF]
, 2017 Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.OBJECTIVES: To assess the cost-effectiveness of basal insulin regimens for adults with type 1 diabetes mellitus in ...
Amiel, Stephanie A +4 more
core +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Some notes on Goodman's marginal-free correspondence analysis [PDF]
arXiv, 2022 In his seminal paper Goodman (1996) introduced marginal-free correspondence analysis; where his principal aim was to reconcile Pearson correlation measure with Yule's association measure in the analysis of contingency tables. We show that marginal-free correspondence analysis is a particular case of correspondence analysis with prespecified weights ...
arxiv
Cost–utility analysis in educational needs assessment [PDF]
Evaluation and Program Planning, 2008 Educational needs assessments (hereafter NAs) are inattentive to cost considerations and are frequently dominated by elite stakeholder groups. In this article I make a case for adopting a cost-utility approach, illustrating the argument with data generated in a NA of central library services in a Canadian school district.
openaire +4 more sources
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
A review of univariate and multivariate multifractal analysis illustrated by the analysis of marathon runners physiological data [PDF]
arXiv, 2022 We review the central results concerning wavelet methods in multifractal analysis, which consists in analysis of the pointwise singularities of a signal, and we describe its recent extension to multivariate multifractal analysis, which deals with the joint analysis of several signals; we focus on the mathematical questions that this new techniques ...
arxiv
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Cost-utility and cost-benefit analysis of pediatric PCV programs in Egypt
Human Vaccines & Immunotherapeutics, 2022 New vaccine introductions (NVIs) raise issues of value for money (VfM) for self-financing middle-income countries like Egypt. We evaluate a pediatric pneumococcal conjugate vaccine (PCV) NVI in Egypt from health payer and societal perspectives, using ...
JP Sevilla +7 more
doaj +1 more source