Results 81 to 90 of about 1,129,710 (262)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Cost function for low-dimensional manifold topology assessment. [PDF]

Sci Rep, 2022
Zdybał K, Armstrong E, Sutherland JC, Parente A.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Faster RCNN mixed-integer optimization with weighted cost function for container detection in port automation. [PDF]

Heliyon, 2023
Bandong S, Nazaruddin YY, Joelianto E.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Testing for the Impact of Skill-based Technologies on Employment of the Workforce in Iran [PDF]

پژوهشهای اقتصادی, 2013
On one hand, the skill-based technologies increase productivity and output, reduce inflation and raise income. On the other hand, human skills are essential for implementing, adopting, utilizing physically and practically of modern and imported ...
Mostafa Emadzadeh, Karim Azarbayjani, Saeed Samadi, Masuod Sadeghi   +3 more
doaj  

Cost Function Determination for Human Lifting Motion via the Bilevel Optimization Technology. [PDF]

Front Bioeng Biotechnol, 2022
Tang B, Peng Y, Luo J, Zhou Y, Pang M, Xiang K.   +5 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Cost-Effective and High-Efficiency Novel 15-Level Hybrid MLI Topology for Renewable Energy Systems

Gazi Üniversitesi Fen Bilimleri Dergisi
In this paper, a new hybrid model for single DC source multilevel inverters (MLIs) is proposed. The proposed switched diode (SD) and high frequency link (HFL) hybrid structure utilizes a single DC source voltage and supplies multiple DC voltages to the ...
Murat Karakılıç, Hasan Hataş
doaj   +1 more source

Diffusion adaptive filtering algorithm based on the Fair cost function. [PDF]

Sci Rep, 2021
Guan S, Cheng Q, Zhao Y, Biswal B.
europepmc   +1 more source