Results 31 to 40 of about 5,884 (248)

Análisis de los costos de la producción bananera durante la pandemia del COVID - 19, provincia de El Oro, periodo 2020

Agroecosistemas, 2021
La producción bananera, es uno de los sectores económicos más importante del Ecuador, debido al aporte que brinda en materia de tributos y plazas de empleo para miles de familias a lo largo de las provincias donde se produce la fruta; el objetivo de la ...
Chuquirima Espinoza, Samuel Efraín , Betancourt Gonzaga, Víctor Alberto , Chávez Cruz, Robert Bolívar   +2 more
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Comentarios sobre el Régimen Especial del Grupo de Entidades en el Impuesto sobre el Valor Añadido (I) [PDF]

Crónica Tributaria, 2018
El autor, en dos partes, comenta el contenido, características y finalidad del denominado «régimen especial del grupo de entidades» en el IVA, a partir del estudio de la normativa y doctrina europeas, así como de la legislación y doctrina españolas; para
Domingo Carbajo Vasco
doaj  

Accounting management of property, plant and equipment under international standards in tourist transport companies

Revista Arbitrada Interdisciplinaria Koinonía, 2020
The objective of this research is to propose an optimal accounting management system for property, plant and equipment for the tourist land transport sector of Azuay. Non-experimental descriptive type.
Daysi Yessenia Ortiz-Jara, Héctor Espinoza-Pillaga, Verónica Paulina Moreno-Narváez   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Los costes en la evaluación de intervenciones farmacéuticas. Los costes en farmacoeconomía

Farmacéuticos Comunitarios, 2011
La evaluación económica de las tecnologías sanitarias, como cualquier intervención farmacéutica, precisa identificar con el mayor detalle posible todos los recursos utilizados en la implementación de la misma. El primer aspecto que se tendrá en cuenta es
Sanz Granda A
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

switching costs

, 2008
Switching costs arise when transactions, learning, or pecuniary costs are incurred by a user who changes suppliers (including for ‘follow-on’ or ‘aftermarket’ products such as refills and repairs). The ex post market power that switching costs give suppliers need not create inefficiencies, and early ‘bargain’ prices can compensate consumers for later ...
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source